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Published by RANZCO
"Clinical and Experimental Ophthalmology Conversations” is the official podcast of Clinical & Experimental Ophthalmology. It provides in-depth, behind-the-scenes interviews with authors of hot topic papers from the journal. Each episode discusses a recently published manuscript, highlighting key findings, clinical impact and how new evidence is shaping ophthalmic practice. Designed for ophthalmologists, orthoptists, optometrists and nurses, the series bridges research with real-world application. “Clinical and Experimental Ophthalmology Conversations” delves into authors’ personal perspectives, areas of debate and insights into the future of the field of ophthalmology. Subscribe and listen to stay at the forefront of innovation in ophthalmology.
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Transpupillary Thermotherapy (TTT) is a globe-salvage local laser treatment that has been used for the treatment of smaller choroidal melanomas. In this retrospective study of 850 patients from Sweden, long-term outcomes including local recurrence and disease-specific survival were found to be worst with TTT alone, followed by combined plaque brachytherapy with TTT, then plaque brachytherapy alone. This raises questions over whether TTT should have any role in the treatment of uveal melanoma and highlights the importance of correct local therapy in reducing long-term mortality from metastases.
Reticular pseudodrusen (otherwise known as subretinal drusenoid deposits) are an important finding in age-related macular degeneration. They are a risk for geographic atrophy development and growth. In this study, an internally and externally validated deep-learning algorithm was developed to automatically identify reticular pseudodrusen with similar to better accuracy than retinal specialists. This allows for future quantification of reticular pseudodrusen in clinical trials, an important next step to learning more about the importance of this sign.
This large case series from Australia reviews 40 patients with tattoo associated uveitis. Most cases were found to be bilateral. Although all forms of uveitis are possible, anterior uveitis is the most common presentation, occurring in 70% of eyes. Vision was commonly affected, such that two-thirds of patients required long term immunosuppression. Given that 25% of the Australian population has a tattoo, asking for this is a critical question in any patient presenting with uveitis.
A recent systematic review and meta-analysis of studies on dominant optic atrophy found that visual acuity was the only biomarker with longitudinal data, and its rate of change did not differ significantly from zero. These findings highlight a critical gap in the field - robust, sensitive biomarkers capable of capturing disease progression are lacking. Identifying alternative structural, functional or molecular biomarkers will be essential for designing and validating future therapeutic clinical trials in dominant optic atrophy.
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Observed September 20, 2026.
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