Peptide of The Week

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover building muscle at 13.5% body fat, running carnivore diet on "R", St. John's Wort interactions, peptides for a marathon at 53, the mitochondrial stack sequenced properly, and whether IGF-1 LR3 and HGH can be run together. Chapters: 00:00 – Intro & Holiday Weekend Recap 00:39 – Shark Stories & Ocean Safety Talk 07:35 – School, Coaching & Warrior Maker Updates 08:18 – Q&A: Muscle Gain & a Shredded Stomach (Age 43) 15:11 – Q&A: R & Fat Digestion on Carnivore 20:59 – Q&A: St. John's Wort & Peptide Interactions 24:39 – Q&A: KPV for Connective Tissue Disease 27:42 – Q&A: Low Energy on Tirzepatide & AOD (Age 38) 36:05 – Q&A: How Long Do Unmixed Peptides Last? 38:36 – Q&A: Do Peptides Show Up on Drug Tests? 40:35 – Q&A: Stacking HGH, CJC/Ipa & IGF-1 LR3 47:36 – Q&A: Marathon Training Stack After Major Weight Loss 51:40 – Q&A: Sequencing Mitochondrial Peptides for Energy (Age 55) 56:53 – Outro & New Hyperbaric Chamber Announcement We cover: • Building Muscle at 13.5% Body Fat as a Woman: Why eating more not less is the answer, why AOD should come out, and why 5-Amino-1-MQ, SLU-PP-332, and Tesamorelin-Ipa are the right additions • Carnivore Diet on "R" with Ulcerative Colitis: Why high fat plus slow gastric emptying causes the problem, why small frequent meals fix it, and why a little fiber and 50 grams of carbs around training goes a long way • St. John's Wort & "R" Interactions: Why R is broken down by protein enzymes not the liver's CYP450 system, why St. John's Wort is notorious for drug interactions, and why milk thistle, TUDCA, and glutathione are better liver support • Mixed Connective Tissue Disease & KPV: Why oral BPC and KPV are generally safe to add, and why coming off a biologic requires a knowledgeable doctor not a podcast • Low Energy on Tirzepatide at 133 Pounds: Why under-eating protein is the most likely culprit, why tracking macros is more powerful than any peptide, and why NAD, SS-31, MOTS-C, and methylated B12 are the right energy stack • Lyophilized Peptide Shelf Life The Real Answer: Why unmixed peptides last up to two years in a cool dark place, why freezing creates moisture risk, and why the crisper drawer in a small fridge is all you need • Do Peptides Show Up on a 5-Panel Drug Test: Why no standard workplace panel tests for peptides and why only high-level professional sports testing would even attempt it • HGH vs IGF-1 LR3 — Can You Stack Both: Why CJC-Ipa is redundant once you're on HGH, when combining HGH and IGF-1 LR3 adds benefit vs. risk, and why MK-677 may be the smarter muscle-building add-on • Marathon Prep Stack at 53 Down 87 Pounds: Why Wolverine is non-negotiable at this age and mileage, why Cardarine and SLU-PP-332 are the endurance game changers, and why adding HGH now gives it time to work before December • Mitochondrial Stack for a 55-Year-Old Working at 2:30 AM: Why SS-31 comes first for at least two weeks, when to layer in MOTS-C, why NAD timing doesn't matter, and why Dihexa, magnesium glycinate, and glycine round out the protocol You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Peptide Of The Week Website: https://peptideoftheweekpod.com Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas get back to basics and break down two compounds people have been asking about. ARA-290 for nerve pain and neuropathy, and 5-Amino-1MQ for fat burning and metabolic optimization. Two very different compounds with very different objectives. Chapters: 00:00 – Intro & Show Plugs 02:37 – New Podcast Format Announcement 03:28 – ARA-290: Redefining Nerve Pain & Repair 05:09 – Nerve Injury Stories: Sciatica & Back Surgery 08:03 – How ARA-290 Works: Macrophage Reprogramming 13:15 – Dosing Protocols & Cost 15:47 – Nerve Pain, Surgery & Long-Term Nerve Damage 17:39 – Tips: Timing, Sleep, Nutrition & Exercise 22:23 – Side Effects, Safety & What to Stack With 24:59 – Compound #2: 5-Amino-1MQ for Fat Burning 27:32 – Real User Results & Fat Loss Data 30:00 – Dosing: Oral vs. Injectable & Cycle Length 33:16 – Zone 2 Cardio & Maximizing Fat Burn 37:37 – Stacking with GLP-1s & Breaking Plateaus 40:49 – Outro, Feedback & Next Episode Preview We cover: 🧠 ARA-290 — Nerve Repair and Neuropathic Pain – First discovered and researched in the early 2000s, still experimental but with human trials – Selectively binds to the Tissue Protective Receptor (TPR) on immune cells, nerve cells, and metabolic tissues – Reprograms macrophages from pro-inflammatory to anti-inflammatory, actually healing the nerve instead of masking pain – Used for small fiber neuropathy, sarcoidosis, autoimmune nerve conditions, diabetic neuropathy, and post-viral recovery including long COVID – Unlike painkillers, effects continue AFTER you stop taking it because it is healing the nerve, not just covering the pain Real-world reports: – Burning pain dropped from a 7 out of 10 to a 2 out of 10 within 3 weeks in diabetic neuropathy patients – Mood lift and mental calm reported within 4 days (not the main intention but consistently reported) – Nerve fiber density measurably increases over days to weeks – Effects often persist 3 to 6 months post-cycle What to stack with: – BPC-157 and TB-500, NAD+, alpha lipoic acid, methylcobalamin, and B vitamins What to avoid: – NSAIDs and corticosteroids will blunt the effects – Alcohol, high sugar, ultra-processed food, and chronic sleep deprivation all work against nerve healing 🔥 5-Amino-1MQ — The Fat Burning Compound – Not a peptide, technically a small molecule compound. First developed around 2014 – Blocks NNMT (Nicotinamide N-Methyltransferase), which is massively upregulated in obese fat tissue and actively drives fat storage – Blocking NNMT shifts your metabolism to burn fat instead of store it, essentially injecting keto without the diet – Also replenishes NAD+ levels that have been depleted with age – In animal studies: obese mice lost 7 to 9% of fat with no loss of lean muscle while eating the same amount of food – Adds an additional 7 to 9% fat loss on top of GLP-1 results because it works on a completely different pathway Who it is for: – Anyone on a GLP-1 who has plateaued, this will relight the fire – People with insulin resistance or pre-diabetes, it increases insulin sensitivity – Already lean people looking to get even leaner and enhance body composition – People with metabolic syndrome or NAD+ depletion Best stacks: GLP-1 (especially R), MOTS-C, NMN, NAD+, L-Carnitine, Alpha Lipoic Acid, CoQ10 Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Peptide Of The Week Website: https://peptideoftheweekpod.com/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover managing high hematocrit on TRT, why HDL drops on testosterone, navigating peptide social media censorship, peptide dosing math broken down simply, hair loss and DHT blockers, and protocols for insulin resistance and PCOS. Chapters: 00:00 – Intro & School Platform Update 01:20 – Coaching Program Update & New Coaches 03:48 – Website Launch & Losing Social Media Channels 04:40 – Personal Life & Family Updates 07:13 – Upcoming Hawaii Trip 08:52 – Teaching Discipline: The Jax Story 12:23 – Q&A: Managing High Hematocrit on TRT 21:33 – Q&A: Insulin Resistance & Weight Loss 28:24 – Q&A: Peptide Dosing Math Explained 36:41 – Q&A: Navigating Social Media & Regulation 44:29 – Q&A: Low HDL on TRT 49:06 – Q&A: Adjusting Your Stack After Reaching Goal Weight 58:35 – Q&A: Hair Loss & DHT Blockers on TRT 1:07:24 – Q&A: Microplastics in Backwater Vials 1:10:14 – Q&A: PCOS, ACL Recovery & Building Muscle & Outro We cover: • High Hematocrit & Thick Blood on TRT: Why testosterone shuts off your body's governor on red blood cell production, why dehydration skews the reading, and why donating blood twice a year is the single best fix • Insulin Resistance & Slow Fat Loss in Women: Why cardio is making it worse, why 40 grams of protein right when you wake up matters, and why walking 10 minutes after every meal may do more than any peptide • Peptide Dosing Math Explained Simply: A live walkthrough of how to calculate exact milligrams per unit for GHK-CU, KPV, MOTS-C, C-Max, and "R" so nothing gets wasted • Navigating Social Media Censorship as a Peptide Educator: Why JD's YouTube got pulled for a 10-minute fasting post, why algorithms are replacing human judgment, and why School and owned platforms are the only safe play • Going Down on "R" After Reaching Goal Weight: Why 5 migs every two weeks makes no sense given the half-life, why 2-3x weekly dosing works better, and when to swap Tesamorelin for 2 IU of HGH • Low HDL on TRT — What Actually Helps: Why niacin has been proven not to work, why aromatase inhibitors make it worse, and why mono-unsaturated fats and fasting are the real levers • Hair Loss, DHT, Finasteride & Dutasteride: Why you're going to lose your hair if your family did regardless, why DHT blockers tank libido and mood, and Will's strategy of microdosing for 3 days to reset without the side effects • Plastic vs. Glass Bacteriostatic Water Vials: Why benzyl alcohol pulls microplastics from plastic vials over time and why glass is the cleaner long-term choice • 32-Year-Old Female with PCOS & ACL Tear: Why Tesamorelin-Ipa blend is the right starting point, why "R" at 500 mcg is virtually nothing, and why protein immediately after waking is non-negotiable 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with Dani Carroll, a holistic health coach with 17 years of experience, Ayurvedic specialist, and yoga teacher. This one is not about peptides. It is about the thing most of us completely overlook that could be undermining everything else we do. Water. Chapters: 00:00 – Intro & Meeting Dani Carroll 01:05 – Dani's Autoimmune Story & Failed Treatments 07:00 – Discovering the Water That Changed Everything 11:11 – First Results: Brain Fog, Joint Pain & Skin 13:00 – Testing It on Her Skeptical Parents 17:56 – Why Isn't Anyone Talking About Water? 19:17 – The Truth About Tap & Bottled Water 25:44 – How Bottled Water Degrades in Transit 27:47 – RO & Distilled Water: The Mineral Problem 29:46 – Understanding pH & the Alkaline Water Scam 34:06 – JD's GERD & Gut Health Case Study 41:19 – Chlorine, Showers & Skin Absorption 50:04 – How the Machine's Settings & Hydrogen Water Work 1:14:04 – Checking Your Own Tap Water (EWG Database) 1:21:13 – Five Rules for Drinking Water & Outro We cover: 💧 Dani's story – Autoimmune disease surfaced at 16, misdiagnosed with rheumatoid arthritis, full body joint pain and monthly skin peeling episodes – Spent years going through every elimination diet, raw vegan, autoimmune paleo, nothing lasted beyond 90 days – Gut microbiome destroyed by antibiotics prescribed by doctors who never addressed the root cause – Discovered structured alkaline water during postpartum depression, within 45 days her skin stopped peeling for the first time in years – 90 days in she was glowing. Her father lost weight, eliminated gout, and cleared acid reflux within months 🧬 Why water matters more than food – You can survive 40 days without food. You die in 3 days without water. Yet nobody talks about water quality – Tap water contains chlorine, fluoride, heavy metals, pharmaceuticals, forever chemicals, pesticides, and herbicides – The chemicals in tap water are often added to protect aging city pipes, not to clean your water – Water softeners add salt or potassium to protect your pipes, they are not designed to be consumed – RO filtered water strips all minerals. Drinking it long term leaches minerals from your bones, causing bone density loss and eventually osteoporosis – Plastic bottled water is dead water that sits in your stomach, does not absorb properly, and leaches microplastics 🚿 Your shower is a bigger problem than you think – You absorb approximately one liter of water through your skin during a 10 to 15 minute hot shower – Pores open in hot water, you inhale chlorine vapor, and your body absorbs it all The 7 pH settings explained: – 2.5 pH (hypochlorous acid): kills E. coli, MRSA, and bacteria. Use to sanitize meat, surfaces, and as mouthwash – 11.5 pH (strong alkaline): veggie wash, makeup remover, skin treatment, poison ivy compress, eczema protocol. Neutralizes pesticides and herbicides which are designed to be water resistant – 6.0 pH (beauty water): matches your skin and hair pH of 6.4. Use to wash your face and hair, works as a leave-in conditioner without stripping natural oils – 7.0 pH (neutral): neutral rinse water for cooking and final food rinse – 8.5, 9.0, 9.5 pH: drinking water levels depending on your health goals and tolerance Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Follow Dani Carroll: Instagram: https://www.instagram.com/rawsomeyoga/ TikTok: https://www.tiktok.com/@rawsomeyoga Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover why SS-31 has been a game changer for JD, how to properly sequence the mitochondrial stack, NAD reactions and replacements, when to come off R, building muscle at 12% body fat, fertility protocols while on TRT, and whether you really need to plan your protocols a year in advance. Chapters: 00:00 – Intro & Personal Health Updates 03:06 – SS-31 & Finding the Right Protocol 06:04 – Disneyland Trip & Kids' Sports Talk 13:48 – Warrior Makers Coaching Program Launch 18:37 – School Platform Updates & Podcast Feedback 21:58 – Q&A: Sleep, Hormones & Energy for a Busy Mum 34:15 – Q&A: Major Weight Loss & a Bad NAD Reaction 39:07 – Q&A: Peptide Storage & Condensation 41:50 – Q&A: SS-31, MOTS-C & NAD Sequencing 49:31 – Q&A: Coming Off Retatrutide's Maintenance Dose 55:22 – Q&A: TRT & Fertility Protocols 1:08:14 – Q&A: Gut Health Flare-Up & Peptide Pause 1:14:53 – Q&A: Runner Wanting Muscle Over Fat Loss 1:21:14 – Q&A: Building a Smart Annual Peptide Plan 1:29:13 – Outro & Coaching Call Details We cover: • Why JD Is Feeling the Best He Has in Years: Why higher-dose SS-31 gets the credit, why less compounds often means feeling better, and why starting with two compounds and adding slowly is the smarter approach • NAD Allergy What to Do Instead: Why reactions to NAD may come from the compound itself not just contamination, why SS-31 at five-plus megs is the closest alternative, and why blood work and hormone optimization should come first at 35 • Peptide Storage and Condensation on Vials: Why condensation on the outside of a vial does not mean moisture got inside, and why a dedicated mini fridge beats any canister solution • Mitochondrial Stack SS-31, MOTS-C and NAD Sequenced Properly: Why SS-31 plugs the holes before MOTS-C revs the engine, why quarterly month-long SS-31 cycles make sense, and why NAD can run anytime regardless • 42-Year-Old Australian Female Should You Come Off R: Why she probably doesn't need it at all, why 5-Amino-1-MQ and SLU-PP-332 are the right replacements, and why discipline is a better long-term tool than any GLP • Fertility Protocol at 33 While Trying for a Baby: Why TRT doesn't have to stop, why HCG and Kisspeptin together improve fertility odds, and why Enclomiphene is the smarter choice over standard Clomid • Building Muscle at 12% Body Fat and Running 60-70 Miles a Week: Why all that running is burning off the muscle she's trying to build, why cutting back to HIIT and lifting heavy is the real answer, and why low-dose testosterone may matter more than any IGF-1 • Total T of 420 at 43 Is It Time for TRT: Why 420 with low energy is answer enough, why TRT will change his life, and why planning protocols a full year out is overrated for most people • How to Build a Smart Annual Protocol Without Overcomplicating It: Why JD and Will plan four months at a time, why trying too many compounds at once tells you nothing, and why the gateway compounds R and BPC are always the right starting point 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down virtually with Dr. Ksenia, known as Dr. K, a functional medicine doctor based in Miami who specializes in hormone replacement therapy, peptides, and weight loss. This one is packed with real clinical insight, especially for the ladies. Chapters: 00:00 – Intro & Welcoming Dr. K 01:34 – Her Specialties: HRT, Peptides & Weight Loss 02:34 – Why Hormones Are Crashing in Young Men 05:57 – Why Doctors Skip Free Testosterone Testing 08:38 – Sleep, Food & Exercise: The Real Fix 09:48 – Women's Hormone Symptoms & Menopause Myths 14:07 – Finding Your Testosterone "Sweet Spot" 19:00 – Cream vs. Injection & What "Normal" Really Means 25:30 – Retatrutide vs. Tirzepatide for Inflammation 27:21 – Peptides for Athletes & Why BPC Is Banned 31:09 – Overhyped Peptides: MOTS-c, SS-31 & IGF-1 LR3 39:41 – The Ideal Longevity Stack & Real Healing Stories 49:42 – Muscle as the Foundation of Healthy Aging 54:53 – Fasting, Gut Health & Psychedelics 1:04:40 – Fertility Q&A, Dr. K's Personal Stack & Outro We cover: 🧬 Why hormones are crashing in young people – Post-COVID, many men saw testosterone drop significantly, viral illness and vaccines both suspected but no confirmed research yet – Athletes with concussion histories frequently present with low testosterone due to trauma-induced endocrine dysfunction – Excess body fat aromatizes testosterone into estrogen, tanking levels even in young men – Free testosterone is the most important marker, not total, and most insurance doctors never run it – A 12-minute appointment cannot solve a hormone problem, personalized medicine is the only answer 🦋 Women and hormones, the orchestra – Women are not one hormone, they are estrogen, progesterone, testosterone, DHEA, and cortisol all working together – Low estrogen symptoms: hot flashes, night sweats, mood swings – Low progesterone symptoms: inability to stay asleep, anxiety, restlessness – Low testosterone symptoms: zero libido, no motivation, no desire to train – SSRIs are being prescribed for menopausal symptoms instead of hormones, which kills libido and solves nothing – Menopause raises cholesterol because the liver keeps making it to synthesize hormones that are no longer being produced. Giving statins instead of hormones is the wrong answer – Dr. K injects herself with 2 to 3mg of testosterone twice weekly and felt dramatically better within three weeks 💉 Testosterone for women – Injectable testosterone at 10 to 15mg is well within normal female range and will not cause masculinization – Creams work but require a higher concentration to hit therapeutic dose – Compounded injectable estrogen (estrogen cypionate) is an option now that patch shortages are happening – Pellets are not recommended by Dr. K, injectables or creams only – Always monitor labs and adjust based on individual response 🔬 SS-31 vs MOTS-c, setting the record straight – MOTS-c does not create more mitochondria, it reroutes energy. Dr. K has reviewed 80% of MOTS-c studies and finds no evidence it makes more mitochondria – SS-31 stabilizes cardiolipin in the mitochondrial membrane, which is how ATP production is stabilized. This is the real deal – Every person over 40 should consider SS-31 for longevity Follow us on social media: Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Follow Dr. K: Instagram: https://www.instagram.com/dr.kseniamiami/ About Dr. K: https://kseniapetrushkina.com/ Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas are joined by peptide consultant Michael Vandal for a deep dive into peptide sensitivity reactions, how to spot a fake Janoshik COA, fixing cortisol and sleep, insulin resistance on secretagogues, and how to bulk while staying on R. Chapters: 00:00 – Intro & How Michael Joined the Team 03:36 – Warrior Maker Coaching Program Launch 07:49 – More Than Fitness: Business & Community 08:28 – Personal Life Updates 10:28 – Q&A Begins 11:14 – Q&A: Peptide Hypersensitivity & Histamine Reactions 18:30 – Q&A: Adding Tessa to a Hyrox Athlete's Stack 23:13 – Q&A: How to Verify a Janoshik COA 26:10 – Q&A: High Estrogen & R Plateau (Age 57) 38:19 – Q&A: Cortisol, Water Retention & Sleep Fixes 48:12 – Q&A: Muscle Maintenance After Cancer Surgery 55:01 – Q&A: Do Collagen Peptides Actually Work? 58:52 – Q&A: Insulin Resistance & GLP Stacking 1:05:45 – Q&A: R Dosing for Bulking 1:13:06 – Q&A: Losing the Last 15 Pounds 1:17:10 – Outro & Coaching Program Reminder We cover: • Severe Peptide Sensitivity to CJC and Wolverine: Why blended peptides use a binding ingredient that some people are genuinely allergic to, why single peptides are the right next step, and why sourcing should be questioned first • How to Verify a Janoshik COA and Spot Fakes: Why the unique code at the bottom is everything, how to verify it on Janoshik's site, and why photoshopped COAs always crop out that code • 44-Year-Old HYROX Athlete — Add Tesamorelin or Go Straight to HGH: Why HGH wins at 44, why SLU-PP-332 helps endurance and nutrient partitioning, and why bumping Wolverine to at least 1 mig daily matters for athletes • High Estrogen on TRT with No Symptoms: Why 1067 total T explains the elevated estrogen, why the three symptoms to watch for are the real indicator, and why an AI is not needed without symptoms • Cortisol, Water Retention and Wrecked Sleep — Non-DSIP Solutions: The glycine, ashwagandha, magnesium glycinate and slow-release melatonin protocol that fixed JD's sleep, why Selank beats Semax for cortisol, and why Epithalon helps reset circadian rhythm • Collagen Peptides — Do They Actually Work: Why powdered collagen supplements produce modest results at best and why BPC, TB-500 and GHK-CU are the real collagen peptides worth taking • 53-Year-Old Female Post-Gastrectomy and Mastectomy: Why HGH and secretagogues are off the table, why SS-31 plus MOTS-C are the right longevity tools, and why creatine is non-negotiable for muscle preservation • Insulin Resistance on Secretagogues: Why growth hormone peptides blunt insulin sensitivity over time, why pulling the secretagogue is the first move, and why an endocrinologist should be in the picture • Bulking While on R: Why dropping to 1.5 migs every five days keeps food noise at bay while allowing enough appetite to eat for muscle, and why protein per pound of body weight is the only number that matters • 27-Year-Old Down 80 Pounds — Last 15 to Lose: Why adding muscle is the only way to raise metabolism enough to drop the final pounds and why SLU-PP-332, 5-Amino-1-MQ and MOTS-C hit fat from three different angles 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with their personal functional medicine doctor and longtime friend, Dr. Scott Collie, for a deep dive into blood work, cardiovascular health, gut health, thyroid, and what actually matters when you are running gear or peptides. Chapters: 00:00 – Intro: Dr. Scott & Talking Real Food (Italy Recap) 05:29 – The Truth About "Running Gear" 06:15 – TRT vs. Steroid Cycles Explained 10:22 – Why Bloodwork Timing Matters On vs. Off Cycle 12:58 – Blood Sugar, Insulin & GLP-1s 17:45 – Kidney, Liver & Iron Health Markers 22:25 – Understanding Cholesterol: LDL, HDL & VLDL 27:31 – Thyroid Health & Hashimoto's 30:06 – Homocysteine & Methylation 35:13 – Rapid Weight Loss & Gallbladder Risks 39:16 – Inflammatory Markers & Heart Damage Warning Signs 46:02 – Top Supplements & Peptides for Cycle Support 53:41 – Cycle Timing & When to Test Blood 1:01:51 – Hydration & Final Thoughts 1:06:07 – Outro & Where to Find Dr. Scott We cover: 🩺What functional medicine actually looks at – Standard doctor panels are a snapshot, not a full picture – Dr. Scott runs up to 75 markers including cardiovascular, inflammatory, kidney, thyroid, and gut markers – Most insurance doctors stop at LDL and HDL, missing the full story completely – You need particle size, not just cholesterol weight, to understand your true cardiovascular risk 🫀 Cardiovascular markers that matter – APOB: umbrella marker for all arteriosclerotic particles including VLDL, LDL, and IDL – Particle size is critical: anabolic steroids shift particles to small dense LDL, the type that sticks and clogs arteries – Myeloperoxidase and LP-PLA2: direct markers of vascular inflammation most doctors never run – Triglycerides plus elevated liver enzymes (AST/ALT) almost always means fatty liver, no ultrasound needed – Fibrinogen: a clotting protein made by the liver, high fibrinogen plus high insulin plus high triglycerides is a walking time bomb, especially for steroid users – CRP (C-Reactive Protein): one of the best inflammatory markers available, if it is high something serious is going on 🧬Homocysteine, the underrated killer – Homocysteine scars the inside of your arteries so plaque particles can park and stick – Now being studied as an Alzheimer's marker as well – Dr. Scott wants it at 7 or below, many people are at 9 to 50 – Fix: methylate with B6, B12, and methyl folate, simple and cheap – TRT alone will elevate homocysteine, so methylating is a must for anyone on testosterone ⚖️Retatrutide and rapid fat loss, what to watch – Losing fat very fast can back up bile flow and cause gallstones, not kidney stones – Check alkaline phosphatase and GGT before starting Reta if there is any gallbladder history – Signs of gallbladder issues: bloating, belching, pain under right rib cage, high-fat meal distress, floating stools – Floating poop is not a good sign, it means fat is not being absorbed properly – Blood sugar, triglycerides, and inflammatory markers improve dramatically and quickly on Reta 🩸Blood work timing for gear users – Best time to test: before the cycle starts, to establish your baseline – After the cycle ends: retest to confirm you returned to baseline – Mid-cycle testing will look alarming by design, be ready for that – If you do not know what different esters are, you are not ready to run gear Follow Dr. Scott Collie: Website: https://heydrscott.com/ Facebook: https://www.facebook.com/DrScottCollie/ Instagram: https://www.instagram.com/hey_dr_scott/ Join The Community: https://www.skool.com/peptideoftheweekcommunity Follow us: Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover Achilles tendon surgery recovery, why CJC histamine reactions are increasing, getting off Adderall at 18, switching from Tirzepatide to Retatrutide, running HGH with IGF-1 LR3, and whether peptide blends really mix evenly.Chapters:00:00 – Intro & Warrior Makers Coaching Launch03:56 – Building Better Men & YouTube Ban Update06:15 – Where to Find the Podcast (Spotify, Rumble & More)07:27 – Upcoming Guest: Water & Hydration08:57 – School Platform & Free Resources09:51 – Q&A: Peptides for Achilles Surgery Recovery (Age 68)13:51 – Q&A: Switching CJC/SS31 for Muscle Gain (Age 41 Female)21:16 – Q&A: Getting Off Adderall Safely (Age 18)27:34 – Q&A: Transitioning from Tirzepatide to Retatrutide33:27 – Q&A: Do Wolverine Blend Ratios Mix Evenly?37:21 – Q&A: Running IGF-1 LR3 with HGH40:17 – Q&A: Best Stack When Cycling Off Retatrutide44:17 – Q&A: Low Sex Drive, LH & HCG Protocol (Age 44)52:28 – Q&A: Cutting Body Fat Before Vacation (Age 33)56:19 – Q&A: HGH vs IGF-1 for Lean Muscle (Age 42 Female)59:44 – Outro & Coaching Call ReminderWe cover:• Achilles Surgery Recovery for a 68-Year-Old: Why starting Wolverine three weeks before surgery matters, why hyperbaric chambers expedite healing, and how to keep her moving without overdoing it• CJC Histamine Reactions Are Increasing: Why JD is hearing more and more bad reactions and why switching to Tesamorelin is the smarter, safer move for women• Tesamorelin Dosing for Women: Why 500 micrograms is the right starting point, why bumping in 250 mcg increments prevents water retention, and why AOD stacked with Tessa transforms women's bodies• 18-Year-Old Getting Off Adderall: Why C-Max, Tesofensine and Dihexa are the peptide answer and why getting off drugs isn't pain-free no matter what you take• Tirzepatide to Retatrutide Transition for a HYROX Athlete: Why pulling the band-aid and starting at 3 migs works, why SLU-PP-332 helps with nutrient partitioning and endurance, and why Thymosin Alpha-1 handles inflammation• Do Peptide Blends Mix Evenly in the Syringe?: Why aqueous solutions mix uniformly unlike oil and water and why this concern is probably overthinking it• HGH vs IGF-1 LR3 Can You Run Both?: Why JD runs them together regularly, why there's no definitive proof it's dangerous, and why HGH alone already blows away any secretagogue• Should You Take Breaks from Retatrutide?: Why tolerance builds over time, why Tesofensine is a good weaning tool, and why building your base means you shouldn't need it forever• Police Officer at 21% Body Fat Getting Ripped: Why HCG should run alongside TRT, why MK-677 may be a better choice than HGH right now, and why fasting is the most underrated tool for men over 40• 42-Year-Old Female with No IGF-1 Response to Secretagogues: Why timing before blood draw skews results, why 1 IU of HGH is the cleanest answer, and why AOD plus Tesamorelin is the best women's fat-burning duoYou're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/aboutSubscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down live for the first time in studio with Jay Campbell, the godfather of TRT, bestselling author, and one of the most respected voices in peptides and optimization. This one goes deep. Chapters: 00:00 – Intro 00:09 – Welcoming Jay Campbell 03:53 – How JD Met Jay Campbell 05:24 – Jay's Inner Work & Letting Go of Ego 13:47 – Books That Shaped Jay's Mindset 19:14 – From Corporate Wage Slave to Entrepreneur 28:18 – Growth Through Adversity & Marriage 32:55 – Masculine/Feminine Dynamics 39:53 – Being Present as a Father 45:51 – State of the Peptide Industry & Fake Products 48:28 – Regulation, FDA & the Future of RUO 57:30 – Why Doctors Resist Peptides & How to Source Safely 1:15:02 – New Peptide Innovations: Clotho, Lepto & More 1:23:48 – Jay's Personal Stack & Key Supplements 1:39:18 – Foundations First: Diet, Discipline & Fasting 1:55:32 – Book Plug & Outro We cover: 🧠 The upper game board of life – Jay's been doing ego deconstruction work with a spiritual coach since November, 9 months in – Two game boards: the lower (money, success, achievement) and the upper (becoming an ethical human being) – Most driven men are unknowingly chasing their father's validation, identifying that changes everything – Sobriety and internal work are the foundation of real growth, JD and Will share their parallel journey 🔬 The peptide industry, what's coming – 95% of people speaking about peptides have no idea what they're talking about – American Peptide Association working toward a single-source triple validation certification, expected by end of 2027 or early 2028 – CGMP, green-lit Chinese facilities only, avoid telegram list sourcing at all costs – Fake Retatrutide being sold for $59.99, if you're buying it that cheap, you know it's fake – The integrity of the owner is the only real difference between a research use company and a 503A pharmacy ⚗️ SS-31 vs MoTC, the new intel – Don't stack SS-31 and MoTC together, run them in separate month-long cycles – If stacking: MoTC during the week, SS-31 on weekends – High dose SS-31: a trusted source is doing 15 to 30mg daily for one month, describing it as the greatest physique transformation of his life – SS-31 massively upregulates cardiolipin, jacks mitochondrial oxidative capacity, veins pop, dramatic leanness 💊 Metformin, the underrated longevity tool – 250mg XR AM and PM, increases Akkermansia in the microbiome – Akkermansia is the last line of gut defense, kills SIBO, Candida, and makes you virtually impervious to respiratory illness – Also improves insulin sensitivity, glucose control, and HDL – Stop a week before a power meet, transiently lowers IGF-1 max output 🔥 BAM (BioBam), the strongest thermogenic Jay has ever used – 2 grams per day (250mg caps, 2 AM and 2 PM to start, build to 4 caps twice daily) – Burns pure fat, does not touch muscle – Run 4 to 6 week cycles, do NOT stack with MoTC, SS-31, NAD+, or SLUPP – Stack with Bio-Recharge (C60, pomegranate, Urolithin A) to protect mitochondria 🧪 This isn't theory, this is real-world experience working with hundreds of people and seeing what actually works. 📺 Subscribe for more no-fluff peptide education every week. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Follow Jay Campbell: Website: https://jaycampbell.com/free-info/ Instagram: https://www.instagram.com/jaycampbell1971/ Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! Will's back from Italy engaged! In this week's Peptide Q&A, JD Denham and William T. Haas cover what peptides to stop before blood work, how to sequence a cellular rebuild stack, Tesamorelin timing on Retatrutide, TRT for a truck driver with total T of 396, and why a pituitary tumor changes everything. Chapters: 00:00 – Intro & Welcome Back 00:40 – The Proposal Story 07:00 – Upcoming Weekend Retreat Announcement 09:00 – Big Guests Coming to the Podcast 11:39 – Q&A: Peptides to Stop Before Blood Work 13:28 – Q&A: Cellular Rebuild Stack & Sequencing 23:22 – Q&A: Sermorelin & Ipamorelin Dosing 29:49 – Q&A: BPC-157 Sublingual vs Oral 32:26 – Q&A: Reconstituted Reta Shelf Life 36:36 – Q&A: TRT Protocol for Low Testosterone 43:14 – Q&A: Timing Tesa/Ipa with Reta 48:25 – Q&A: Combining Multiple Peptides in One Injection 49:20 – Q&A: HGH vs CJC/Ipa Timing with GLP-1 50:36 – Q&A: Muscle Growth Peptides with Pituitary History 53:19 – Prague Trip Recap 59:54 – Outro & Feedback Request We cover: • What to Stop Before Blood Work: Why secretagogues, MK-677, HCG, Kisspeptin and biotin can all skew your labs and how long to stop each before testing • Cellular Rebuild Stack all at Once or Sequenced?: Why Fox04 first clears the trash, why SS-31 must come before MOTS-C, and why throwing the kitchen sink in at once defeats the purpose • Epithalon Dosing Explained: Why 100 migs twice a year is the standard, why 10 migs for 10 days and 5 migs for 20 days are both correct, and why Paul Bakhtiar starts everyone here • Sermorelin + Ipamorelin at 260 Down to 238 should You Up the Dose?: Why a caloric deficit blunts IGF-1 response, why winning streaks aren't the time to add more, and how to use plateau busters instead • BPC-157 Sublingual vs Oral for Gut Health: Why BPC was born in gastric juices and why oral capsules beat sublingual for gut-specific use every time • How Long Can You Keep a Reconstituted Retatrutide Vial: Why 28 days is the bacteriostatic water standard not a cliff edge and why buying the right vial size solves the problem • TRT Protocol for a Truck Driver with Total T of 396: Why high body fat raises estrogen and SHBG, why 180-200 migs of test twice weekly is the starting point, and why life changes in three weeks • Tesamorelin + Ipamorelin Timing When on Retatrutide: Why morning fasted dosing beats nighttime circadian alignment when GLP-1 is slowing gastric emptying and why the two peptides should never be split up • HGH vs CJC for Muscle Growth Over 50: Why actual HGH wins every time and why splitting the dose morning and night is worth exploring • Benign Pituitary Tumor What Peptides Are Safe: Why HGH and secretagogues are off the table, why creatine and protein are the real answer, and why IGF-1 LR3 still carries risk 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham is joined by Nora Adam (Wholesale Director at Forge Bio Lab) and Tiffany Marie Davis nutrition practitioner, peptide integration specialist, and retired IFBB Pro for a deep dive into gut health, hormone optimization, functional testing, and why most people are being dismissed by the very system that's supposed to help them. Chapters: 00:00 – Intro & Guest Introductions 01:18 – Tiffany's Fertility Story & Being Dismissed by Doctors 04:43 – Becoming a Nutrition Practitioner 06:08 – Functional Testing vs Standard Labs 09:34 – Vaccine Injury Case & Medical Gaslighting 17:22 – Why Doctors Dismiss Patients 19:30 – The Gut-Brain Connection 20:14 – Top 3 Root Causes: Trauma, Food, Eating Disorders 27:25 – The Anti-Inflammatory Diet 33:19 – How Peptides Actually Work 36:33 – GLP-1s: Benefits, Risks & Misuse 39:45 – Minerals, Copper & GLP-1 Side Effects 44:52 – Fasting & Autophagy: Women vs Men 54:49 – Where to Start If You Feel Unwell 1:02:46 – Outro & Where to Find Tiffany & Nora We cover: 🦋 Tiffany's story – Competing as an IFBB Pro destroyed her hormones by age 26 hair loss, amenorrhea, miscarriage, dismissed by every doctor she saw – Doctors threw metformin, birth control, and dismissals at her none addressed the root cause – A doctor refused to prescribe T3 because she assumed Tiffany wanted it for weight loss she then miscarried – Went back to school, earned 13 certifications in nutrition, became a board-registered nutrition practitioner – Now works entirely in functional testing and root cause healing 🩺 What functional testing actually reveals – Standard labs are a snapshot they don't tell you WHY – Most doctors only run one thyroid marker there are eight – Elevated LDL on keto, carnivore, or RETA is expected your doctor probably doesn't know that – APOB + hs-CRP are far better cardiovascular risk markers rarely tested – Functional tests Tiffany runs: gut zoomer, hormone zoomer, organic acids test, heavy metals, mycotoxins, mineral panel, celiac, food sensitivities 🔥 The three root causes she sees most – Trauma: held in organs (gallbladder = resentment/anger), disrupts the gut-brain axis, spikes cortisol, blocks proper hormone signaling – Food: our food supply is not the same as 30 years ago — seed oils, dyes, GMO crops, herbicide-sprayed produce, and modified grains are destroying gut linings – Eating disorders: nutrient deficiencies and intestinal abuse from restriction, bingeing, or purging cause cascading hormone and gut dysfunction 💊 GLPs — the missing piece nobody talks about – Women losing hair and nails on GLP-1s are malnourished gastric emptying slows nutrient absorption – Must pair with: magnesium, electrolytes, copper mineral, digestive enzymes, liver support (TUDCA + ergothioneine) – Copper deficiency is extremely common on GLP-1s and almost never tested – GLP-1s are a tool not a lifestyle. Use them to build momentum, fix the base alongside them 📺 Subscribe for more no-fluff peptide education every week. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Follow our guests: Tiffany Marie Davis: Instagram: https://www.instagram.com/tiffanymarie_davis/ Website: https://www.tiffanymariedavis.com/ Nora Adam: Instagram: https://www.instagram.com/glowithnora Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas are live from Prague after touring the Janoshik testing facility the gold standard for independent peptide testing. They break down what they saw, how COAs actually work, what testing really costs, and answer questions on fat loss at 447 pounds, chronic pain peptides, and the hardest peptide to test. We cover: • Inside Janoshik: What the Tour Actually Looked Like: Why Peter Magic's team does things right, what the petri dish sterility test looks like in person, and why endotoxins are caught at the supplier stage • How COAs Actually Work The Full Breakdown: Purity vs. identity vs. content testing, what HPLC and mass spectrometry actually measure, and why a COA without all three tells you almost nothing • What Peptide Testing Actually Costs: $450 for HPLC, $105 for heavy metals, $180 for endotoxins, $290 for sterility and why that math explains why cheap products can't be properly tested • The Hardest Peptide for Janoshik to Test: Why Cerebrolysin tops the list, why it's made from pig brain and contains multiple peptide strains, and why Retatrutide is challenging due to its molecular weight • Opiate Painkillers Post-Surgery When to Get Off: Why ibuprofen often works better than Vicodin for actual pain, why ARA-290 is the peptide answer for nerve pain, and why hyperbaric chambers and red light accelerate healing • 447 Pounds Down to 380 What to Stack with Retatrutide: Why TRT is non-negotiable first, why HGH at 2 IU is the long play, and how SLU-PP-332, 5-Amino-1-MQ and L-Carnitine target fat through different pathways • Carnivore + Retatrutide Does It Work?: Why you can absolutely do both, when to use carbs strategically around training, and why intermittent fasting compounds the results • The Culture at Janoshik: Why Czech work culture prioritizes quality over speed and what American businesses can learn from it Chapters: 00:00 – Intro 00:09 – Life in Prague 02:37 – Cutting Out Negative People 09:04 – Jet Lag & Life Update 10:29 – Impressions of Janoshik Testing Facility 15:39 – Female Weight Loss, Muscle Retention & Reta Dosing 22:29 – Crohn's Disease & GI Symptoms 28:15 – Big Toe Inflammation & Injection Placement 36:10 – Healing Off Pain Meds Safely 43:31 – Fat Loss Stack for Major Weight Loss Journey 55:19 – Peptide Storage & Shelf Life 1:00:12 – What Surprised Them About Janoshik's Testing Process 1:07:31 – Starting a Peptide Business & Finding Reliable Suppliers 1:21:33 – Contamination Testing Explained 1:25:59 – Cost & Types of Peptide Testing 1:31:10 – Hardest Peptides to Test Accurately 1:34:00 – Outro & Team Shoutouts You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas pull back the curtain and share the story behind the podcast, the friendship, and the companies how two guys from Alcoholics Anonymous ended up building something neither of them planned. Chapters: 00:00 – Intro 00:09 – How the Peptide of the Week Podcast Began 05:11 – Business Partners With Opposite Strengths 09:27 – JD's Wife's Relapse Changed Everything 13:58 – Will's Rock Bottom & Path to Sobriety 17:20 – The AA Meeting That Built a Brotherhood 22:41 – From Fitness Coaching to Building a Company 28:23 – How the Podcast Took Off 33:53 – Building a Business Around Integrity 42:30 – Are Entrepreneurs Born or Made? 49:08 – The Values Behind Their Success 51:18 – Future Guests & Final Thoughts We cover: 🙏 How it all started – JD's wife relapsed six months after they got married a rough patch that changed everything – A phone call from a man in AA stopped JD from making a decision he would have regretted forever – To support his wife, JD started attending a Monday night AA meeting and that's where he met Will's sponsor – Will had just gotten out of jail after a fentanyl overdose got a sponsor, started going to meetings – Will's sponsor brought him to JD's house for a Wednesday night book study at 6PM – Two guys became three, then five, then COVID hit and meetings shut down – JD's living room turned into a 70+ person AA meeting every Wednesday night – Without that relapse, without that meeting none of this exists 💪 How fitness connected them – Both were deep into health, supplements, and fitness – After meetings they'd talk for hours about compounds, diets, what was working – Will was always running something JD was always curious about it – That passion for health was the bridge from friendship to business 🎙️ How the podcast happened – JD started a fitness channel and wanted to interview Will in his garage first video was on HGH and MK-677 – Second video in the backyard. Third on the beach in Huntington Beach but nobody could hear it – Their editor suggested making it a podcast it just worked – Hit 100,000 viewers and neither of them knew what that meant – Now at 600,000+ monthly viewers still growing 🏢 How the company started – JD was selling a carnivore diet plan and people wanted the supplements he used – Will was supplying him JD doubled the price and sold them – Will needed to raise prices they decided to just partner up – Flew to Vegas for a business conference, sat down for 10 minutes and recorded a video on a compound that was the first real episode – Became 50/50 partners neither wanted to fight over percentages – Started in a garage, moved to a small office in Huntington Beach, now 15+ employees 🔑 Why it works – Total opposites JD is the face, the storyteller, the social media guy. Will is the builder, researcher, and operational engine – What JD loves most: the podcast. What Will loves least: the podcast. Perfect. – Neither can do what the other does they need each other and they both know it – No ego, no greed, no micromanaging just trust and mutual respect 📺 Subscribe for more no-fluff peptide education every week. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover whether HGH and IGF-1 LR3 can be stacked safely, why libido stays low even on TRT, Wolverine protocols for a 69-year-old with nine surgeries, why peptides don't show on drug tests, and how to dose BPC and TB-500 for a 125-pound dog. Chapters 00:00 – Intro 00:09 – Newport Dunes, Family Trip & Prague Plans 03:24 – The Future of Peptide Testing & COAs 09:32 – HGH vs. IGF-1: Should You Stack Them? 18:56 – Wolverine Stack for Surgery & Injury Recovery 22:00 – Healing the Gut with BPC-157 & KPV 26:45 – RETA, Weight Loss & High LDL Explained 30:27 – Why GHRHs & GHRPs Work Better Together 34:07 – Low Libido on TRT: What You're Missing 42:13 – Do Peptides Show Up on Drug Tests? 44:39 – RETA, Muscle Gain & Increasing Your Metabolism 50:58 – Ulcerative Colitis, Wegovy & Switching to RETA 53:16 – Using Peptides for Dogs & Surgery Recovery 55:56 – Peptides Before Surgery, Fasting Protocol & Community Updates We cover: • HGH + IGF-1 LR3 Together Safe or Not?: Why doubling up amplifies muscle building but also amplifies insulin sensitivity risk and who should and shouldn't do it • Why GHRH and GHRP Work Better Together: How Sermorelin and Ipamorelin amplify each other's pulses and why Tesamorelin plus low-dose Ipa is the best combo for women prone to water retention • 69-Year-Old LEO with Nine Surgeries: Why high-dose Wolverine is safe, why two migs of each daily post-surgery is the target, and why injecting close to the site matters • Diverticulosis & Ulcerative Colitis Protocol: Why oral BPC and KPV are the foundation and why most medications are probably making the gut worse • High LDL on Retatrutide in Women: Why rapid fat loss temporarily raises LDL, why it's not alarming at 106, and why the scale is the wrong metric to chase • Low Libido at 44 on TRT: Why free testosterone matters more than total, why 100 migs may be too low, and why diet, sleep, cortisol and estrogen all outrank more testosterone • Do Peptides Show Up on Drug Tests: Why no standard employment test screens for peptides and why the economics of testing make it nearly impossible • Gastric Sleeve Patient Stalled at 145 Pounds: Why eating more protein not fewer calories is the fix and why adding Tesamorelin and Ipamorelin raises your BMR over time • Switching Mom from Wegovy to Retatrutide: Why going pound for pound on dosage is the simplest approach and why she'll feel hunger again and that's okay • Wolverine Protocol for a Saint Bernard Post Spinal Surgery: Why a human-sized dose is appropriate for a 125-pound dog, what the beagle studies show, and how to inject intramuscular You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down GHK-Cu, the Glow stack, and the Klow stack what they are, how they work, how to use them properly, and why they belong in almost everyone's protocol. Chapters: 00:00 – Summer Plans, Travel & Prague Lab Visit 05:00 – Why Vacations Matter & Working Smarter 09:59 – Touring Janoshik Labs & Quality Testing 12:32 – GHK-Cu, Glow & Klow Explained 19:48 – How to Use GHK-Cu Face Serum Correctly 22:55 – GHK-Cu Shampoo & Hair Growth Benefits 29:04 – Why RETA Pairs Well with GHK-Cu 32:13 – Buffered Reconstitution & Reducing Injection Sting 33:51 – Glow vs. Klow vs. Wolverine Stack 46:09 – GHK-Cu Dosing, Cycling & Copper Safety 49:55 – Tattoos, Healing & Final Takeaways We cover: 🧬 What is GHK-Cu? – Copper peptide its primary job is signaling your body to produce more natural collagen – Reduces and corrects skin inflammation – Helps with wound healing, skin elasticity, fine lines, wrinkles, dark spots, and hair thinning – GHK-Cu levels decline from ~200 ng/mL at age 20 to ~80 ng/mL at age 60 that decline shows up on your face – Sub-Q injecting GHK-Cu has been shown to darken hair pigmentation — biochemically based, not hearsay – GHK-Cu vs Minoxidil: GHK-Cu was found favorable in trials for hair growth – A wound healing double-blind clinical trial on topical GHK-Cu serum is scheduled for 2026 💉 How to use the Face Serum correctly – Use a dermal roller first opens the skin so it absorbs properly – Clean the roller in alcohol before use – Apply serum after rolling 3 days per week is the sweet spot – Works if you just apply it, but works significantly better with the roller – JD and his wife cut laser facial healing time in half using it friend who skipped the serum healed much slower – Do NOT use numbing cream with the dermal roller Will learned this the hard way 🧴 GHK-Cu Shampoo – Leave it in for 1.5–2 minutes before rinsing longer contact = better results – Prolongs the hair follicle growth phase and stimulates thicker follicle growth – Won't regrow hair on a completely bald scalp, but does make a noticeable difference – A hairdresser in Orange County was blown away by results on her own thinning hair now sells it in her salon 🌟 Glow Stack (GHK-Cu + BPC-157 + TB-500) – GHK-Cu: collagen production, skin repair, wound healing – BPC-157: signaling peptide finds injuries, reduces inflammation, converts food into collagen building materials. Origin story: the peptide that prevents stomach acid from burning through your stomach lining – TB-500 (Thymosin Beta-4): recruits stem cells, sends them where BPC-157 directs, reduces inflammation, accelerates tissue repair – Together: BPC finds the problem, TB-500 sends the workforce, GHK-Cu builds the collagen 💪 Klow Stack (GHK-Cu + BPC-157 + TB-500 + KPV) – Everything in Glow PLUS KPV for gut health – KPV calms gut inflammation, helps leaky gut, modulates immune response – Most autoimmune issues start in the gut KPV addresses the root – Best all-in-one health and healing stack available 📺 Subscribe for more no-fluff peptide education every week. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover why women respond differently to Retatrutide, how to mix multiple peptides into one vial, bulking stacks without anabolics, Crohn's disease protocols, loose skin after major weight loss, and long-term maintenance foundations. Chapters: 00:00 – Prague Trip & Behind-the-Scenes Lab Tour 05:07 – Mixing Multiple Peptides Into One Injection 11:37 – RETA vs. Tirzepatide for Weight Loss 22:06 – Storing Peptides the Right Way 24:03 – Best Peptides for Energy, Anxiety & Cortisol 28:51 – Building Muscle Without Anabolics 36:18 – Injection Sites, TRT & Reducing PIP 41:00 – Loose Skin, Weight Loss & GHK-Cu 46:32 – Lean Bulking, IGF-1 & Muscle Growth 51:31 – Long-Term Maintenance & Favorite Stacks 56:45 – Crohn's Disease, Gut Health & BPC-157 1:00:01 – Fasting, Recovery & Final Takeaways We cover: • Mixing Multiple Peptides Into One Vial: Live demo of combining BPC, TB-500, KPV and Thymosin Alpha-1 for Will's mom the math, the method and what never to combine • Wife Lost 100 Pounds on Tirzepatide but Stalled on Retatrutide: Why men lose faster, why she's probably not eating enough, and why Tesamorelin plus resistance training is the next move • Peptide Storage Freeze or Refrigerate: Why freezing causes moisture risk and why the crisper drawer in the fridge is all you need for up to six months • 24-Year-Old Female Always Tired & Anxious: Why eating more protein is likely the fix, why Selank and Semax are the right peptide pairing, and why blood work should come first • Rotating Injection Sites & Scar Tissue: Why you must rotate within the same area, what scar tissue feels like, and why injection speed matters more than most people realize • Loose Skin After Major Weight Loss: Why Klow, GHK-CU Snap-8 serum and Tesamorelin address it from every angle • Lean Bulk Without Anabolics at 34: Why IGF-1 LR3, MK-677, creatine and high protein are the best non-anabolic stack and why Retatrutide works against a true bulk • Retatrutide vs Tirzepatide for Wife Struggling with Food Noise: Why bumping Retatrutide slowly and adding resistance training beats switching back • MOTS-C — Daily vs Three Times Weekly: Why there's no conclusive answer yet, why five migs at once can feel like pre-workout, and why Tesofensine is worth a trial • Crohn's Disease Protocol: Why oral BPC and KPV are the first move, why carnivore and fasting give the gut a chance to heal, and why the liver needs rest too • Long-Term Maintenance Foundation: Why TRT, HGH and occasional low-dose Retatrutide with hard work is all you ever really need 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with Josh Holyfield fitness coach, educator, and one of the most straightforward voices in the peptide and optimization space. This one gets into blood work patterns, the real problems with Western medicine, gear cycles, HGH science, and why most men are failing before they even start. Chapters 00:00 – Meet Josh Holyfield 01:16 – From Fitness Coaching to Peptide Education 06:29 – Why He Walked Away from High-Ticket Coaching 10:04 – Why Traditional Medicine Falls Short 15:36 – The FDA, Pharma & the Future of Peptides 20:49 – Blood Work Every Man Should Understand 24:25 – Low Testosterone: Fix the Foundation First 28:23 – Helping Men Transform Their Lives 34:27 – Favorite Anabolics & Building Muscle 37:19 – Growth Hormone, IGF-1 & Recovery 45:10 – Optimizing Steroid Cycles Safely 55:11 – Enhanced Games, Sports & Final Thoughts We cover: 🩺 What Josh actually sees on blood work – Most men are walking around with total testosterone between 300–500 and most doctors think that's fine – Low T is often a sleep and diet problem first not a TRT problem – Elevated LDL on keto or RETA is expected your doctor doesn't know that – APOB + HSCRP are better predictors of cardiovascular risk than LDL alone — and most doctors don't test for them – Statins remove cholesterol the raw material your testicles use to make testosterone. Doctors prescribing statins to low T men are making the problem worse – Women are almost universally under-eating this is the #1 issue Josh sees 🏥 Why Western medicine is failing – Doctors aren't malicious they're programmed, incentivized, and legally constrained – FDA is funded by the pharmaceutical companies it regulates – Insurance companies dictate treatment guidelines not patient outcomes – A drug that cures at 79% for $5 can't go to market if a 95% drug exists at $10,000 that's the law – Peptide regulation is coming but so is more freedom for doctors to prescribe them 💉 HGH — the science behind timing – GH converts to IGF-1 in the liver that's what builds muscle – Insulin and IGF-1 compete take GH fasted so it can do fat burning and repair FIRST – Morning dosing: just came off an 8-hour fast, pituitary still gets its natural 2–3AM pulse – Night dosing: shuts down your natural pulse for ~18 hours you lose the freebie – On GLP-1s: morning GH is even more important since RETA keeps insulin elevated for days – Josh's dose: 6 IU before bed, fasted spectacular results ⚗️ Favorite Compounds — Round Table – Josh: Testosterone cypionate daily (long ester), Masteron E, micro-dose Tren, EQ for aromatizers. Never needed an AI even at 600mg test/week – JD: Low test base, Winstrol to kick start, Masteron, occasional Primo. AOD, 5-Amino-1MQ, Testofensine, HGH 2 IU – Will: Sustanon 3x/week, Masteron, Winstrol, Cardarine for athletic performance. HCG 1500 IU + HMG for fertility prep. Low dose RETA twice/week for brain function 🧠 Real talk on gear – More gear is not always better diminishing returns are real above 800mg test – Anavar is a starter drug because people are scared Winstrol actually does more – If you don't know the difference between esters, you're not ready 📺 Subscribe for more no-fluff peptide education every week. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Follow Josh Holyfield: Instagram: https://www.instagram.com/josh.holyfield/ YouTube: https://www.youtube.com/@josh_holyfield Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover a teenage son with chronic boils, TRT for weight loss and low energy, MCT vs seed oil carriers, fasting on Retatrutide, fertility protocols for special forces veterans, and what to do when MOTS-C causes a lasting reaction. Chapters: 00:00 – Studio Updates & Upcoming Guests 09:15 – Gut Health, Immunity & Healing Protocols 14:09 – TRT, Weight Loss & Low Testosterone 20:03 – Women's Hormones, Energy & ADHD 26:01 – Fat Loss, Libido & TRT Optimization 32:00 – Injection Reactions & MOTS-c Side Effects 34:23 – Gut Inflammation, IBD & Healing Peptides 39:08 – Anxiety, Depression & Brain Peptides 41:36 – TRT, Carrier Oils & Performance 49:42 – Fasting, RETA & Muscle Retention 53:09 – Fertility, TRT & Family Planning We cover: • Teenage Son with Chronic Boils & Gut Issues: Why stopping antibiotics, running oral BPC and KPV, and getting a stool test done may matter more than any peptide • TRT at 45 with 300 Pounds to Lose: Why waiting for weight loss to fix testosterone is swimming upstream and why starting low-dose TRT now changes everything faster • ER Nurse with ADHD, Celiac & Low Energy: Why Modafinil beats Adderall long term, why Selank and Semax are the right pairing, and why hormones need to be checked first • Low Energy & Low Libido on Retatrutide + TRT: Why rapid fat loss suppresses natural testosterone, why Kisspeptin doesn't work on TRT, and why HCG is the right call instead • MOTS-C Allergy — What To Do: Why some people simply can't tolerate it, why SS-31 and NAD cover most of the same ground, and why Paul Bakhtiar has the same reaction • IBD Protocol for Wife: Why oral and injectable BPC plus KPV are the right tools and how long you can realistically run them • PSA Concerns on High-Dose TRT: Why DHT management matters, what estrogen symptoms to watch for, and when finasteride or dutasteride may be needed • Coming Off Anti-Anxiety Meds: Why Selank, Semax, Tesofensine and PE2228 cover anxiety and depression from different angles and why meditation and movement still matter most • Low Testosterone at 30 in Australia — MCT vs Seed Oil Carriers: Why MCT wins on purity and dispersal, why Proviron enhances TRT naturally, and what to watch for with post-injection pain • Fasting on Retatrutide: Why Retatrutide actually protects muscle during fasting through insulin signaling and why training fasted accelerates results • Special Forces Vet Trying for Baby #2: Why HCG, HMG and N-Clomiphene together beat Clomid alone and why TRT during conception is more doable than most doctors admit 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham (live from Cabo) and William T. Haas break down Will's top 5 fat burners, JD's real-world stacks for a 47-year-old man needing to lose 70 pounds, a menopause protocol, and what a 21-year-old athlete should actually be taking. We cover: 🔥 Will's Top 5 Fat Burners (in order) – Retatrutide: triple agonist GLP-1, GIP, and glucagon. The undisputed #1. Kills food noise, keeps brain sharp while fasted, no hangry response. Nothing comes close – Cagrilintide: the appetite suppressant add-on Reta is missing. Better and safer alternative to stacking tirzepatide with Reta - Novo Nordisk already made Cagrisema for a reason – HGH: boosts metabolism, improves sleep, builds lean muscle, reduces fat. You notice it most when you stop. HGH Frag 176-191 and AOD are great honorable mentions for those already lean – Tesamorelin: the only compound proven to spot-burn visceral fat. FDA approved. Dose at night fasted for best results do NOT take at the same time as Reta (insulin blunts it) – MOTS-C: exercise mimetic on a cellular level. Thousands of people reporting great fat loss results. Boots energy, ATP, and keeps you moving more throughout the day – Honorable mentions: SLUPP-332, 5-Amino-1MQ, Tesofensine, Clenbuterol, Cardarine GW501516, T3 thyroid, Liposa/MIC injection, L-Carnitine 💪 JD's Stack — 47-Year-Old Man, 70 Pounds to Lose, Desk Job – Step 1: Get bloodwork - almost guaranteed to be hormonally deficient – TRT: non-negotiable base. Sleep, clarity, energy, sex drive all improve within weeks – HGH: sleep, recovery, anti-aging, lean muscle, fat burning - must for anyone over 40 – Retatrutide: holy grail for fat loss. Works exponentially better when hormonally optimized – Wolverine Stack (BPC-157 + TB-500): he hasn't trained, his tendons need support — mandatory – KPV: 47 years of bad eating has wrecked the gut. Fix the gut, fix everything – Diet: 90-day carnivore, intermittent fasting Mon/Wed/Fri (eat 12–8PM), weight train 4 days/week, HIT training 3 days/week 🦋 Menopause Stack – Cellular energy: NAD+, SS-31 (repair first), then MOTS-C – Mood/brain fog: Semax + Selank together dopamine, serotonin, anxiety relief – Intimacy/dryness: PT-141 goes from first gear to fifth fast – Weight gain: Retatrutide even at low doses for women who don't need major weight loss – Skin/hair/nails: KLOW (GHK-Cu + KPV + BPC-157) collagen, gut health, hair thinning, fine lines 🏊 21-Year-Old Competitive Athlete – Keep it simple their body heals itself – Creatine + high protein + eat more food – Wolverine if they have an injury only peptide worth adding at this age – SLUPP for stamina and nutrient partitioning if needed – No testosterone, no secretagogues, no HGH their body produces plenty – Cardarine would help massively but is WADA banned skip it if competing 📺 Subscribe for more no-fluff peptide education every week. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Join The Community: https://www.skool.com/peptideresearchinstitute/about