Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Do you feel nauseous, dizzy, exhausted, or brain foggy after an Epsom salt bath? If a bath you hoped would help you relax leaves you feeling worse, you might wonder whether you’re experiencing a “detox reaction,” reacting to the heat or struggling to tolerate the Epsom salts themselves. In this short Q&A episode of The Histamine Well Podcast , Joanne explores possible reasons for feeling sick after an Epsom salt bath, including bath temperature, changes in blood pressure, histamine intolerance, mast cell activation and sensitivity to sulfur compounds. Epsom salts are magnesium sulfate. Joanne explains the role of sulfate in a detoxification pathway called sulfation and discusses why people use Epsom salt baths as part of their detox routines. She also shares why feeling unwell afterwards should not automatically be interpreted as a sign that a treatment is working—or a reason to push through. If you’ve been searching for answers about Epsom salt bath side effects , feeling dizzy after a hot bath , or the possible connection between histamine intolerance and Epsom salts , this episode offers a starting point for understanding your reaction and discussing it with your practitioner. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Do eggs, garlic, onions or broccoli leave you feeling bloated, fatigued or foggy-headed? In episode 57 of The Histamine Well Podcast, Joanne explores hydrogen sulfide SIBO and intestinal sulfide overproduction (ISO), discussing how sulfur-producing gut bacteria may contribute to these symptoms. Discover: The connection between sulfur intolerance and the gut microbiome. Why hydrogen sulfide production and clearance both matter. The uses and limitations of stool and breath testing. Joanne’s clinical approach to low sulfur diets, oregano, molybdenum and digestive support. Joanne also discusses where the evidence remains limited and why symptoms alone cannot confirm the cause. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Struggling with constipation on the low-FODMAP diet? If your bloating has improved but your bowel movements have slowed down, what should you consider next? In this short Q&A episode of The Histamine Well Podcast, naturopath Joanne Kennedy shares how she approaches constipation in patients following a low-FODMAP diet. She discusses fibre intake, hydration, digestive support, and the role of the nervous system in bowel regularity. If you’re navigating constipation, SIBO, bloating or histamine intolerance, this episode offers practical topics to discuss with your treating practitioner. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Can an imbalanced gut microbiome contribute to anxiety and depression? We often think of mental health conditions as beginning solely in the brain. However, growing research suggests that the gut microbiome may also influence mood through the gut–brain axis. In this episode of The Histamine Well, Joanne explores what gut dysbiosis is and how the gut communicates with the brain through the vagus nerve, immune signalling, inflammation, stress hormones, short-chain fatty acids and neurotransmitter precursors. Joanne also examines what the research actually says about probiotics, intestinal permeability, depression and anxiety—without overstating the evidence or promising a simple cure. In this episode, you’ll learn: What gut dysbiosis means and what can disrupt the gut microbiome How the vagus nerve connects the gut and brain Why short-chain fatty acids are important for inflammation and brain health How gut bacteria may influence the stress response and serotonin production What studies have found about the microbiome and depressive symptoms Why the evidence for depression is currently stronger than the evidence for anxiety What “psychobiotics” are and why probiotic benefits are strain-specific Why gut health interventions should complement—not replace—appropriate mental health treatment Practical ways to support microbial diversity and the gut–brain axis Why fermented foods and some prebiotic fibres may not suit everyone with histamine intolerance or SIBO The science supports a genuine connection between gut health and mental health, but the relationship is complex. There is no single probiotic, diet or supplement proven to resolve anxiety or depression on its own. Supporting the gut through a diverse, fibre-rich diet, appropriate prebiotic or fermented foods, regular movement, sufficient sleep and stress management may form one valuable part of a broader approach to mental wellbeing. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Could sluggish bile be affecting your digestion, gut health and histamine symptoms? In this episode of The Histamine Well Podcast, Joanne Kennedy explains the essential role bile plays in fat digestion, nutrient absorption, liver detoxification and microbial balance. She also explores how poor bile flow may contribute to SIBO, histamine intolerance and increased oxalate absorption. Joanne breaks down four popular bile-support supplements—ox bile, TUDCA, taurine and phosphatidylcholine—including how each works, when it may be considered and why they are not interchangeable. In This Episode, You’ll Learn: Common symptoms of sluggish or inadequate bile flow What happens to digestion after gallbladder removal How poor bile flow may contribute to SIBO and histamine intolerance The connection between fat malabsorption and oxalates How ox bile supports fat digestion How TUDCA supports liver health and bile flow Why taurine is needed to produce functional bile salts How phosphatidylcholine supports bile quality and methylation Important supplement precautions involving gallstones and bile duct obstruction Listen now to understand how bile affects digestion—and how targeted support may benefit your liver, gallbladder and gut health. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well , Joanne explores the powerful connection between stress, cortisol, mast cell activation, and histamine intolerance. She explains how chronic stress can keep the nervous system trapped in fight-or-flight mode, trigger histamine release, and contribute to symptoms such as itching, flushing, headaches, sinus congestion, digestive issues, and skin reactions. You’ll learn how the HPA axis responds to stress, why cortisol is helpful in the short term, and what can happen when the body becomes less responsive to cortisol’s anti-inflammatory effects. Joanne also discusses how reduced vagal tone may affect inflammation, mast cell reactivity, and the body’s ability to return to a calm, regulated state. In this episode, you’ll discover: How stress activates the HPA axis and sympathetic nervous system The connection between cortisol, mast cells, and histamine Why chronic stress may worsen histamine intolerance and MCAS symptoms How stress-signalling molecules can trigger histamine release What glucocorticoid resistance is and how it may affect inflammation The role of the vagus nerve in immune and nervous-system regulation Why antihistamines may not address the upstream cause Practical ways to improve vagal tone and support nervous-system regulation Joanne also shares simple strategies to help the body shift from fight-or-flight into rest-and-repair mode, including breathwork, humming, singing, gentle neck massage, and other vagus nerve exercises. If your histamine symptoms seem to flare during periods of stress, this episode will help you understand why—and what you can do to begin breaking the stress–histamine cycle. Resources mentioned: The Secret Language of the Body The Workout Witch nervous-system programs ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Could oxalates be the hidden reason your histamine intolerance symptoms aren’t improving? In this popular podcast replay, Joanne is joined by Melanie Peers to explore the often-overlooked connection between oxalates, histamine intolerance, inflammation, gut health, and nervous system dysregulation. Oxalates are naturally occurring compounds found in many foods—including some commonly considered healthy. For sensitive individuals, a high oxalate load may contribute to pain, digestive problems, urinary symptoms, fatigue, and increased reactions to foods and supplements. In this episode, Joanne and Melanie discuss: What oxalates are and how they can affect the body The connection between oxalates, histamine, and inflammation Common high-oxalate foods that may be contributing to symptoms Signs and symptoms associated with oxalate overload How gut health may influence oxalate absorption The impact of oxalates on minerals, sulfur, and important detoxification pathways Why some people develop multiple food and supplement intolerances The role of methylation and transsulfuration pathways Why nervous system regulation is an important part of recovery Why oxalates should be reduced carefully rather than eliminated too quickly ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

What is histamine, and why does it cause so many frustrating symptoms? In this replay of one of our most popular episodes, Joanne explains the science of histamine intolerance in a simple, practical way. Learn how histamine affects your immune system, gut health, hormones, brain, and skin, why histamine levels become too high, and the common symptoms of histamine intolerance—including migraines, anxiety, insomnia, hives, eczema, reflux, bloating, and more. Discover why a low-histamine diet alone isn't enough and why identifying the root cause is the key to lasting relief. Whether you're new to histamine intolerance or revisiting this episode, this is the perfect place to start your healing journey. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

One of our most downloaded episodes is back. If you've been diagnosed with histamine intolerance , MCAS , or unexplained food sensitivities, this replay is one you won't want to miss. In this listener-favorite episode, Joanne Kennedy explains why histamine intolerance is not a diagnosis—it's a symptom of deeper underlying health issues. While many people rely on a low histamine diet to manage symptoms, lasting improvement comes from identifying and treating the root causes driving excess histamine production. Drawing on years of clinical experience, Joanne walks through the most common contributors to histamine intolerance, including SIBO, gut dysbiosis, leaky gut, digestive enzyme insufficiency, mold illness, oxalates, methylation issues, hormonal imbalances, and chronic inflammation. Whether you're a practitioner, student, or someone struggling with chronic histamine symptoms, this episode will help you better understand why histamine intolerance develops—and where to start looking for answers. Listen, Learn & Share If this episode helps you better understand your histamine symptoms, please follow The Histamine Well Podcast , leave a review, and share it with someone searching for answers. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment. In this episode, Joanne explains the difference between histamine intolerance and MCAS, why symptoms overlap, and why some people continue to react despite following a low histamine diet. Drawing on her clinical experience, Joanne explores how histamine is processed in the body, the role of DAO and HNMT enzymes, common triggers for mast cell activation, and why addressing the root cause is essential for long-term recovery. She also discusses the connection between mould mycotoxins, gut dysfunction, SIBO, oxalates, nervous system dysregulation, and histamine-related illness, while sharing practical insights into how she approaches assessment and treatment in clinical practice. In this episode, you'll learn: The difference between histamine intolerance and Mast Cell Activation Syndrome (MCAS) Why these conditions share many of the same symptoms but require different treatment approaches How DAO and HNMT enzymes help regulate histamine in the body Common causes of histamine intolerance, including gut dysfunction, SIBO, mould exposure, oxalates, and hormone imbalances Why MCAS symptoms are often more severe, unpredictable, and triggered by non-food factors The connection between mould mycotoxins, chronic inflammation, and mast cell activation Which laboratory tests may be helpful—and why some commonly recommended tests have limited clinical value Joanne's clinical approach to identifying and treating the root causes of histamine-related symptoms Whether you're navigating histamine intolerance, suspect MCAS, or you're a healthcare practitioner wanting a deeper understanding of these complex conditions, this episode provides practical, evidence-informed insights to help you take the next step towards better health. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause. In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioidentical oestrogen and progesterone. She discusses the signs of low oestrogen and progesterone, the limitations of standard hormone testing, and how bioidentical hormone therapy may support women during this transition. You'll learn: The difference between perimenopause and menopause Common symptoms of low oestrogen and low progesterone How hormonal changes can influence histamine intolerance and mast cell activation Why hormone blood tests don't always tell the full story The potential benefits and challenges of bioidentical oestrogen and progesterone The connection between hormones, anxiety, sleep, mood, energy, libido, and weight Why hormone therapy should be individualised rather than one-size-fits-all Whether you're navigating perimenopause yourself or supporting women through this stage of life, this episode offers practical insights to help you better understand the relationship between hormones, histamine, and healthy ageing. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity. But what if more methylation isn't always better? In this episode, Joanne explores the science behind methylation, the roles of MTHFR and COMT, and why relying solely on genetic reports can lead to inappropriate supplementation. Joanne explains the difference between undermethylation and overmethylation, the symptoms of excess methyl groups, and why many people experience worsening anxiety, insomnia, irritability, and other adverse effects when taking methylated supplements. Whether you're a practitioner, student, or someone navigating histamine intolerance, hormone imbalances, or chronic health concerns, this episode provides a balanced, evidence-informed perspective on one of today's most talked-about health trends. In this episode, you'll learn: What methylation is and why it's essential for health How methylation affects neurotransmitters, hormones, detoxification, and gene expression The difference between undermethylation and overmethylation The role of MTHFR, COMT, folate, and vitamin B12 in methylation pathways Common symptoms of excess methyl groups Why genetic testing alone doesn't tell the whole story The potential risks of methylated supplements A more personalised approach to methylation support ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)? In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle? Joanne breaks down the science behind the estrogen-histamine feedback loop, explains how histamine interacts with estrogen and progesterone throughout the menstrual cycle, and discusses why some women experience worsening mood symptoms during the luteal phase. You'll learn about the role of mast cells, neurotransmitters, neuroinflammation, and hormone sensitivity in PMDD, as well as the potential benefits and limitations of H1 and H2 antihistamines . Joanne also shares her clinical observations on histamine-related hormone symptoms and why addressing underlying drivers of histamine excess may be essential for long-term symptom improvement. In This Episode You'll Learn: What PMDD is and how it differs from PMS The relationship between histamine and women's hormones How estrogen can increase histamine levels The role of progesterone in histamine regulation Mast cell activation and hormone-related symptoms Why histamine may worsen anxiety, irritability, and mood swings The science behind H1 and H2 blockers Potential risks of long-term antihistamine use Histamine's effects on neurotransmitters including serotonin and dopamine The connection between PMDD, MCAS, and histamine intolerance Why methylation may play a role in PMDD symptoms Common root causes of histamine excess, including SIBO, mold exposure, oxalates, and gut dysfunction Natural strategies for addressing histamine-related hormone symptoms ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve. In this episode of The Histamine Well Podcast , Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified. You'll learn how three key factors often work together to impair cellular energy production: Mycotoxins and their direct toxic effects on mitochondria Sulfur depletion and reduced glutathione production Oxalate accumulation and mitochondrial stress Joanne explains how these mechanisms can disrupt ATP production, increase oxidative stress, and contribute to symptoms such as chronic fatigue, brain fog, muscle weakness, exercise intolerance, post-exertional malaise, pain sensitivity, and temperature dysregulation. This episode also explores the important relationship between mould exposure, gut dysbiosis, SIBO, sulfur metabolism, and oxalate overload—factors that are frequently overlooked when addressing ongoing fatigue and recovery from mould illness. Whether you're a practitioner, student, or someone navigating chronic health challenges, this episode provides valuable insights into the biological processes driving fatigue and what may need to be addressed for meaningful recovery. In this episode, you'll discover: How mould toxins damage mitochondrial function Why fatigue often persists despite rest and sleep The critical role of sulfur in energy production and detoxification How oxalates can contribute to mitochondrial dysfunction Common signs of mould-related mitochondrial impairment Why addressing mould exposure alone may not be enough for recovery ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction. If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure may be contributing to ongoing nervous system and digestive dysfunction. Joanne breaks down the mechanisms behind mould-related gut issues, including how mycotoxins impact the vagus nerve, gut motility, stomach acid production, bile flow, pancreatic enzymes, inflammation, and the migrating motor complex. She also discusses why chronic SIBO cases are often difficult to treat when mould toxicity is not properly addressed. In this episode, you’ll learn: Why mould illness and SIBO commonly occur together How poor vagal tone affects digestion and bacterial overgrowth The connection between mould, histamine intolerance, and mast cell activation Why low stomach acid and sluggish bile flow can worsen gut symptoms How chronic inflammation disrupts gut motility and digestive function Why antibiotics and herbal antimicrobials may not fully resolve SIBO The importance of mould testing in chronic gut health conditions #SIBO #MouldIllness #HistamineIntolerance #GutHealth #Mycotoxins #MCAS #FunctionalMedicine #DigestiveHealth #MoldToxicity #VagusNerve ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation. Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms. In this episode, Joanne explains: How poor bile flow contributes to histamine intolerance Why mold toxicity and mycotoxins affect the liver and gallbladder The vicious cycle between SIBO and bile dysfunction How estrogen dominance impacts bile flow and histamine Why oxalates can worsen inflammation and histamine symptoms The role of methylation and phosphatidylcholine in healthy bile production How vagus nerve dysfunction affects digestion and bile release Common signs and symptoms of poor bile flow This episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms. 🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine. #HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast , Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients. High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12. Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements. In this episode, you’ll learn: • What high homocysteine means and why it matters • The connection between homocysteine and methylation • Why methylated B vitamins can trigger symptoms • Histamine intolerance and supplement sensitivity • The role of MTHFR, COMT, and methylation pathways • Overmethylation vs undermethylation explained • Practical clinical insights for improving tolerance to methyl nutrients Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing. Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast , Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms. Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing. This episode also covers: The role of estrogen during menopause and HRT Why over-detoxifying estrogen may worsen symptoms The connection between beta-glucuronidase, the estrobolome, and gut microbiome health Histamine intolerance, hormone imbalance, and menopause symptoms Natural considerations for estrogen metabolism and hormone support Why gut health may be more important than estrogen detox supplements If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight. Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms. This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms. You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected. In this episode, Joanne discusses: The link between SIBO, histamine intolerance, and hormonal imbalance Why bloating, PMS, headaches, and acne may stem from gut dysfunction The difference between hydrogen and methane SIBO How nutrient deficiencies affect hormones, mood, and energy Why is bowel motility essential for successful SIBO treatment The role of biofilms in persistent gut symptoms Functional medicine strategies for improving gut and hormone health Whether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation? In this Q&A episode of The Histamine Well Podcast , Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate) —and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities . You’ll learn how magnesium and sulfate work together in the body, how they’re absorbed through the skin, and why this gentle therapy can support everything from sleep and muscle relaxation to liver detox pathways and gut lining integrity . 🎧 In this episode, you’ll learn: What Epsom salt (magnesium sulfate) actually is How transdermal absorption supports magnesium levels The role of sulfate in liver detoxification (sulfation pathway) Why sulfate is essential for gut lining, skin, and connective tissue health How Epsom salt baths support the nervous system and stress response Why they’re helpful for people with histamine intolerance, sulfur sensitivity, mold illness, and oxalate issues How to safely start Epsom salt baths (especially if sensitive) Epsom salt baths aren’t just about relaxation—they’re a powerful, low-cost tool to support detox pathways, reduce stress, and restore key nutrient levels without burdening the digestive system. This makes them especially beneficial for those who struggle to tolerate supplements or are dealing with complex chronic symptoms. If you’ve ever wondered whether Epsom salt baths actually “do anything”—this episode will give you a clear, science-backed answer and practical guidance. Tune in to learn how to use this simple therapy effectively and safely. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!