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MeSsy with Christina Applegate & Jamie Lynn Sigler

Published by Wishbone Production

  • Personal journals
  • Society & culture
  • Health & fitness

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

Listen on Apple Podcasts, opens in a new tabMake something like it

On the charts

4 chart placements

Every published chart this podcast appears in, in the snapshot behind this page. Each one links to the chart it came off.

  1. Number 75Personal journalsAustralia
  2. Number 29Personal journalsCanada
  3. Number 121Personal journalsNorway
  4. Number 27Personal journalsUnited States

From the feed

Recent episodes

The latest episodes published to this podcast’s own RSS feed. Titles and descriptions are the publisher’s.

  1. Stop Apologizing for Wanting More with Heather Dubrow from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Sep 17, 202654 min

    This week on Living With It, Jamie sits down with Heather Dubrow for an honest conversation about embracing life’s pivots, protecting your peace, and giving yourself permission to want more. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  2. There Is Beauty Within All of This Pain with Lindsey Kraft from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Sep 15, 202654 min

    This week on MeSsy, Jamie sits down with her longtime friend, actress, writer, and musician Lindsey Kraft. They talk about growing up together, navigating rejection and self-doubt, and Lindsey’s unexpected journey from acting to writing her own one-woman musical. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Take the MeSsy Survey - Please help out the show by taking our survey at https://messythepodcast.com/survey Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Lola - Get 40% off select Lola Blankets products at https://lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at k18hair.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  3. Falling Apart to Come Back Together with Ryan Weiss from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Sep 10, 202647 min

    This week on Living With It, Jamie sits down with her friend, Ryan Weiss. They talk about letting go of control, sitting with difficult emotions, knowing when it’s time to do things differently, and learning to trust what’s on the other side when life doesn’t look the way you thought it would. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  4. Thank God I’m So Neurotic with Cat Cohen from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Sep 8, 202647 min

    This week on MeSsy, Jamie sits down with comedian, actor, and singer Cat Cohen. Cat opens up about having a stroke at 31, navigating health anxiety in the aftermath, and turning one of the scariest experiences of her life into her most fulfilling creative work yet. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  5. We Fight For Joy with Kelsey Chittick from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Sep 3, 202653 min

    This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a life she never expected. They discuss finding humor in the darkest moments, letting go of the life you thought you’d have, the power of community, and how to choose joy. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  6. There’s No Place Like Home with Annie Meyers-Shyer from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Sep 1, 202653 min

    This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new passion and career at 45, and why it’s never too late to bet on yourself. Annie also shares how she creates a home that feels like an exhale, the small ways our spaces can support us through difficult seasons, and how her home carried her through grief. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod ZBiotics - Go to https://zbiotics.com/messy and use MESSY at checkout for 15% off any first time orders of ZBiotics probiotics. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  7. The Power of Radical Acceptance with Jim Curtis from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 27, 202653 min

    This week on Living With It , Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you have without giving up hope for the life you want, the stories we build around our suffering, and learning to see your body as an ally instead of the enemy. Plus, Jim shares how releasing old beliefs and changing the way we speak to ourselves can open us up to new possibilities. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  8. Jamie's Son Beau from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 25, 202642 min

    This week, Jamie sits down with a very special guest: her 13-year-old son, Beau. They have an honest conversation about what it’s been like growing up with a mom who has MS, how Jamie’s strength has shaped him, and what he wants other kids and parents living with chronic illness to know. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. MudWtr -Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/messy ! #mudwtrpod OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod MyAlloy - Try the original estrogen-powered M4 skincare from Alloy. Visit myalloy.com and use code MESSYfor $20 off your first order! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  9. Accept, Adapt, Appreciate with Odette Annable from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 20, 202654 min

    This week on Living With It, Jamie sits down with her friend Odette Annable. They discuss parenting a neurodivergent child, trusting your instincts, advocating for your family, and learning to let go of the need to have all the answers. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  10. The Courage to Slow Down from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 18, 202653 min

    This week on MeSsy, Jamie opens up about reaching her limit and learning to make rest part of healing. She also reads listener emails about fighting to be heard by doctors, learning to accept help, and the power of knowing you're not alone. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Lola Blankets - Get 40% off select Lola Blankets products at Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. ZocDoc - Head to https:// Zocdoc.com/MESSY to get started and check that appointment off your to-do list! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  11. Finding Stillness When Life Won’t Slow Down with Bob Roth from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 13, 20261 hr 0 min

    This week on Living With It, Jamie sits down with Bob Roth, a leading Transcendental Meditation teacher and CEO of the David Lynch Foundation. They discuss what stress does to the body, how meditation can help calm the nervous system, and how finding stillness can help us navigate uncertainty, illness, and everyday life. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  12. How Death Informs How We Live with Julie McFadden from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 11, 202658 min

    This week, Jamie sits down with hospice nurse Julie McFadden to talk about changing the way we think about death, what she’s learned from those at the end of life, and how accepting our mortality can help us live more fully in the present. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Take the MeSsy Audience Survey https://www.messythepodcast.com/survey Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad CBDistillery - Visit https:// CBDistillery.com and use my code MESSY for 25% off. That’s C B Distillery dot com , code MESSYC B Distillery dot com. K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at k18hair.com Radiance - For 20% off and FREE SHIPPING. Go to https:// BRICKHOUSENUTRITION.com and use code - MESSY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  13. Trusting the Journey with Becca Tobin from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 6, 202657 min

    This week, Jamie sits down with one of her best friends, Becca Tobin, for a conversation about infertility, pregnancy loss, surrogacy, and finding hope after years of uncertainty. They explore grief, resilience, the unexpected paths to parenthood, and what it means to keep moving forward when life doesn't unfold the way you imagined. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  14. Try to Find the Light with Amanda Kloots from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Aug 4, 202659 min

    This week, Jamie sits down with Amanda Kloots for an honest conversation about finding joy alongside heartbreak. Amanda opens up about losing her husband, Nick Cordero, how her grief has evolved over the past six years, why she no longer believes we have to "let go" of the people we love, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Oak Essentials - Use codeMESSY at https://oakessentials.com to get 15% off your first purchase! #OakEssentials #ad Zbiotics - Wedding season, bachelorettes, rooftop birthdays — August doesn't slow down and neither do you. Pre-Alcohol keeps it that way. https:// ZBiotics.com/MESSY code MESSY for 15% off. Honeylove 0 Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  15. Look for the Signs with Kate Doerge from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Jul 30, 202658 min

    On this episode of Living With It, Jamie sits down with Kate Doerge to discuss finding hope after profound loss, recognizing signs from loved ones, and the five actions that can transform the way we move through grief. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  16. Hope Can Exist Alongside Fear with Myriam Sandler from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Jul 28, 20261 hr 7 min

    This week, Jamie sits down with Mothercould creator Myriam Sandler. They discuss her recent MS diagnosis, trusting your intuition, and finding hope even when life doesn't go as planned. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod CBDistillery - Visit https://CBDistillery.com and use my code MESSY for 25% off. That’s C B Distillery dot com, code MESSY C B Distillery dot com. Radiance - For 20% off and FREE SHIPPING. Go to https://BRICKHOUSENUTRITION.com and use code - MESSY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  17. It's Okay Not to Be Okay with Amy Kurtz from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Jul 23, 202655 min

    On the first episode of Living With It, Jamie sits down with Amy Kurtz, a patient advocate and author. They discuss the grief of chronic illness, learning to trust yourself again, and why healing is about so much more than getting better. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  18. All Eyes on Me from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Jul 21, 202648 min

    This week, Jamie reads listener emails and opens up about the feeling of all eyes on you when you're struggling, the anxiety of the lead up, caregiving, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. CBDistillery - Visit https:// CBDistillery.com and use my code MESSY for 25% off. That’s C B Distillery dot com, code MESSY C B Distillery dot co m. ZocDoc -Head to https:// Zocdoc.com/MESSY to get started and check that appointment off your to-do list! Radiance -For 20% off and FREE SHIPPING. Go to https:// BRICKHOUSENUTRITION.com and use code - MESSY Lola Blankets -Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  19. Tamsen Fadal from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Jul 14, 202656 min

    This week, Jamie sits down with journalist, author, and menopause advocate Tamsen Fadal. They discuss the physical and emotional realities of perimenopause, why so many women feel dismissed by the medical system, and how speaking honestly about aging, identity, and women's health can help us all feel less alone. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Veracity - For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY. Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at ⁠https://rythm.health/messy⁠ Stop guessing, start testing. Rythm DOT HEALTH slash messy Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  20. You Do Not Have to Become Someone Else to Heal from MeSsy with Christina Applegate & Jamie Lynn Sigler, opens in a new tab

    Jul 7, 202651 min

    This week, Jamie reads listener emails and discusses the invisible weight of living with chronic illness, the courage it takes to keep showing up, and the small moments that can bring us back to ourselves. She also shares the reminder she received from a recent on stage performance. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Zbiotics - Go to https://zbiotics.com/MESSY and use MESSY at checkout for 15% off any first time orders of ZBiotics probiotics. Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/ messy #honeylovepod Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy Stop guessing, start testing. Rythm DOT HEALTH slash messy Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Ranking source

Apple Podcasts rankings via the Mato Topic Intelligence Platform.

Observed September 20, 2026.

Apple and Apple Podcasts are trademarks of Apple Inc., registered in the U.S. and other countries.

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