The Hidden Link between MCAS, Orthostatic Intolerance/dysautonomia, and Interstitial Cystitis (IC)

My own personal experience with proteolytic enzymes (from those that support gluten breakdown to the wildly popular nattokinase and serrapeptase) is much different than I expected. Here's what you need to know (whether you're taking these or considering these) even if you don't have: gluten intolerance (and cheat occasionally by popping a handful of enzymes) mast cell activation orthostatic intolerance/dysautonomia (with or without tachycardia) interstitial cystitis Long COVID migraines/severe headaches (and especially if you do). This segment is lifted directly out of Reclaim Wellness Intensive , the program I wish I'd had when I first started struggling with these symptoms (yes, I had all of these at once). P.S. You'll find much more detail about how each of these proteases behaves in the body (whether by upregulating matrix metalloproteinases or the body's own endogenous proteases) inside an upcoming post. P.P.S. For the tau protein part of this episode, proteases are known to cleave tau protein and those fragments are problematic (see references 5, 6, and 7 below). References for this episode: Biancheri P, Di Sabatino A, Corazza GR, MacDonald TT. Proteases and the gut barrier. Cell Tissue Res. 2013 Feb;351(2):269-80. doi: 10.1007/s00441-012-1390-z. Epub 2012 Mar 20. PMID: 22427120. Van Spaendonk H, Ceuleers H, Witters L, Patteet E, Joossens J, Augustyns K, Lambeir AM, De Meester I, De Man JG, De Winter BY. Regulation of intestinal permeability: The role of proteases. World J Gastroenterol. 2017 Mar 28;23(12):2106-2123. doi: 10.3748/wjg.v23.i12.2106. PMID: 28405139; PMCID: PMC5374123. Fedorowski, A., Sutton, R. Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome. Nat Rev Cardiol 20 , 281–282 (2023). https://doi.org/10.1038/s41569-023-00842-w Foote CA, Soares RN, Ramirez-Perez FI, Ghiarone T, Aroor A, Manrique-Acevedo C, Padilla J, Martinez-Lemus L. Endothelial Glycocalyx. Compr Physiol. 2022 Aug 23;12(4):3781-3811. doi: 10.1002/cphy.c210029. PMID: 35997082; PMCID: PMC10214841. Boyarko B, Hook V. Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration. Front Neurosci. 2021 Oct 21;15:702788. doi: 10.3389/fnins.2021.702788. PMID: 34744602; PMCID: PMC8566764. Nübling G, Levin J, Bader B, Israel L, Bötzel K, Lorenzl S, Giese A. Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation. Exp Neurol. 2012 Oct;237(2):470-6. doi: 10.1016/j.expneurol.2012.07.018. Epub 2012 Aug 6. PMID: 22890115. Kostiuchenko O, Kravchenko N, Markus J, Burleigh S, Fedkiv O, Cao L, Letasiova S, Skibo G, Fåk Hållenius F, Prykhodko O. Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota in Healthy C57BL/6 Mice and Dose-Manner Response on Mucosal Permeability in Human Reconstructed Intestinal 3D Tissue Model. Metabolites. 2022 Oct 26;12(11):1027. doi: 10.3390/metabo12111027. PMID: 36355110; PMCID: PMC9696696.

In this episode, you'll discover why adrenal fatigue causes estrogen dominance. For more on hormone health check out: https://brandysearcy.com/the-secret-reason-youre-sick

How do you know if your cortisol's high or low without a lab test? Find out in this episode. For more, subscribe to youtube.com/@feelbetterthanfine Connect with Brandy at hey@rainorganica.com or shesbalanced@gmail.com

We often chase things that don't matter when seeking wellness. I myself have chased low estrogen, migraines, fatigue, weight gain, and chronic UTI symptoms. At the end of the day, the one thing causing all those symptoms was the same...my body couldn't meet energy demands. If you're tired of living life limited by symptoms and frustrated with chasing those symptoms, this episode's for you. Click to listen. Ready to break free of your symptoms? Claim your seat in From Gaslit to Resilient here: brandysearcy.lpages.co/from-gaslit-to-resilient

What tests are necessary to properly evaluate thyroid function? This episode discusses the markers necessary. Hint, some are thyroid hormones and some aren't 🤯 Download that lab test here: brandysearcy.lpages.co/is-tsh-enough-to-determine-low-thyroid And, save your spot in from Gaslit to Resilient here: brandysearcy.lpages.co/from-gaslit-to-resilient

Quantitative fertility monitors are new(er) on the scene, and they're powerful tools for empowered health! Sylvia Kang, founder of Mira Care joins me in this episode to talk about Mira the fertility monitor I use daily. Get the Mira monitor here: mira-fertility.pxf.io/rainorganica Save your spot at the summit here: tinyurl.com/flourish-beyond-40

As our friend estrogen makes her departure, thyroid hormones and cortisol imbalances are revealed. In this episode you'll learn how to support your adrenals and thyroid as estrogen levels fall (spoiler alert... estrogen dominance is really an indication of stressed adrenals!) For more conversation on hormone balance beyond 40, save your seat for this summit: tinyurl.com/flourish-beyond-40

this episode, we're covering lots of symptoms caused by low thyroid. starting out with high cholesterol, blood pressure, and atrial fibrillation in otherwise healthy people and the thyroid connection. Then, in the main part of today's episode, you'll discover why: acne infertility fibromyalgia chronic fatigue syndrome are all symptoms of low thyroid. Then you'll find out why low thyroid's so commonly missed for years (sometimes decades) before being diagnosed. We'll also talk about the cortisol connection with thyroid (cortisol's gotta be just right in order for thyroid hormone to get out of the bloodstream and into the body's cells). Ready to check your symptoms against the full list of low thyroid symptoms? Take the quiz here: https://subscribepage.io/is-it-your-thyroid Find the complete shownotes here

Many symptoms that seemingly have nothing to do with the thyroid gland are in fact due to low thyroid... and, TSH isn't the right test to figure out whether you've got a thyroid problem. Tune into this episode to discover a few of the many symptoms of low thyroid and what needs to be tested to rule out a problem. And, be sure to check out this assessment to see whether your symptoms point to a thyroid problem . Grab your assessment here: subscribepage.io/is-it-your-thyroid (in case that link above doesn't work 🙂)

Get ready to discover the connection between how your energy flows and autoimmunity in this episode. This is your chance to experience a guided energy session completely for free and while the focus may be on autoimmunity, you may just find that your relationships are better and your mind is clearer after this session. Find Jen on her own podcast, Journey with Jen and also check out these episodes: Breaking barriers preventing weight loss Overcoming negative head talk Be sure to subscribe to Holistic Wellness for new episodes.

Integrative nutritionist and health coach Haley Fountain shares the healing power of sound and reconnecting with your body in this episode. Be sure to check out the Tibetan singing bowl meditation 🙂

Massage therapist and yoga instructor, Corynne Smith, reveals how to choose the massage technique that will most help you with specific conditions. Corynne's the founder of Affirmations of Wellness Yoga & Massage Studio in Oceanside, CA.

In this episode, you'll discover why Rain Organica products are universal to all skin types and how 3 products meet all of your skin's needs. For more, check out these related episodes: Why don't children get acne Hydrosol vs. floral water

Liz Murphy shares her reasons for going vegan (hint, it's not just the environmental impact) in this episode of Holistic Wellness. Listen in for how she found plant-based eating beneficial for her health and her mindset. Liz Murphy is the chef and owner of Santosha Nutrition, a plant-based, zero-waste culinary business focusing on farm-to-table experiences and education. In 2021, Liz founded Sustainability is Sexy, a nonprofit focused on driving innovation within the San Diego community through connection and providing tangible education and solutions to the global climate crisis.

Originally from Sweden, Fredrika Syren is an environmental activist, public speaker and writer and book author of “A practical guide to zero waste for families”. She lives a zero waste life is San Diego, California with her husband and three children Isabella, Noah and Liam. Her family has been featured in the documentary “Zero time to waste” and on Ava DuVernay’s TV series “Home Sweet Home”. You can learn more about Fredrika and zero waste on: https://zerowastefamily.com YouTube https://www.youtube.com/zerowastefamily Facebook @thezerowastefamily Instagram @zero.waste.family To watch the documentary for free https://youtu.be/n_fcaQvAofI Fredrika’s book https://www.amazon.com/Zero-Waste-Families-Practical-Guide-dp-8985466003/dp/8985466003/ref=dp_ob_title_bk

Have you ever wondered what steps brands take to make sustainable skincare? In this episode, we'll talk about how sustainable ingredients are made & why this matters for the health of your skin and the planet. This podcast is focused on skincare sold here in the US because it is harder to navigate truly clean skincare from marketing jargon here in the US compared with EU due to looser regulations on skincare. Want to support your health even more? Download the guide 5 easy ways to detox your day here . Other episodes you may enjoy: What's the difference between floral waters and floral hydrosols? What's the difference between US and EU regulations for skincare preservatives? Sustainable Harvest International: Boosting crop yields for small farmers with sustainable agriculture

Karese Laguerre's a myofunctional therapist who works with clients to improve alignment of facial and neck muscles. Because so many conditions (ADHD, sleep apnea, insomnia, brain fog) are exacerbated (or straight up caused by) alignment problems, her work goes far into improving productivity and helping you achieve your tasks with more clarity and efficiency so that ultimately, you're able to accomplish your goals. Connect with Karese at https://themyospot.com and on IG at instagram.com/themyospot Whether you're an entrepreneur with a "to do" list long enough to paralyze anyone, have a corporate job and wondering how you're going to finish this project on time, or have a child struggling with schoolwork, this episode is for you. And, in case your productivity's on point, but you suffer from TMJ or insomnia, this episode's also for you.

After a year and a half of dealing with recurrent UTIs so bad they caused me to miss work and bouncing from one healthcare practitioner to another, taking round after round of antibiotics and still winding up with another UTI once the antibiotic course completed, I finally asked the right question... why? Here's the scoop: that very 1st UTI occurred within 2 weeks of when I stopped using hormonal birth control. Turns out, long-term use of hormonal contraceptives can mess with your blood sugar metabolism. And when I quit cold turkey, my body was seriously insulin resistant and because it didn't have those synthetic hormones around to stimulate it to release large doses of insulin, I wasn't metabolizing my food in a healthy way. In this episode, you'll learn how to recognize whether a blood sugar metabolism problem is causing your UTIs (and maybe even whether it's related to your diagnosis of interstitial cystitis) regardless of whether you've ever used hormonal birth control or have recently stopped using hormonal birth control. This episode's packed with valuable insights and links over to Rain Organica's program which provides practical steps to help your body regain healthy blood sugar balance. Imagine freeing yourself from the endless cycle of recurrent UTIs and reclaiming your health within just one week! So, if you're ready to break free from UTIs and UTI symptoms, hit that listen button. Ready to start your journey to break free from UTIs and UTI symptoms? Access Rain Organica's signature program Natural Relief from UTIs and Interstitial Cystitis here .

Are you struggling with interstitial cystitis (IC), recurring urinary tract infections (UTIs), or fertility issues? Discover how pelvic floor therapy and Mercier Therapy, both natural approaches to fertility challenges and bladder conditions help you reverse symptoms and restore health in this interview with Pelvic Floor and Mercier Therapist Gina Valdez. Mercier Therapy offers hope and relief for women seeking natural fertility solutions and has been found to significantly improve the odds of achieving pregnancy*. It's also an incredible therapy for cycle support, endometriosis, and PCOS. In addition to talking about Mercier Therapy for fertility, Gina offers valuable insight into understanding how you're able to support interstitial cystitis (IC) symptoms, UTI symptoms, and support postpartum recovery by improving the health of your pelvic floor... and by supporting a healthy connection between your bladder and brain. Listen to this episode now for immediate actions to take to support healthier urination and a healthier cycle. And, be sure to subscribe to Holistic Wellness for more empowering discussions around Interstitial cystitis and recurrent UTIs, which happen to be topics I'm well versed in and love talking about to help you avoid the same pitfalls I experienced in my own recovery journey. In fact, check out these previous episodes for more (and be sure to subscribe so you don't miss the next episode dedicated to the underlying cause of IC and recurrent UTIs): How dysregulated sugar metabolism increases your risk of developing a UTI Find out more about Gina here. Follow Pelvic Health & Fertility on IG. Save your spot for the craft body oil workshop here: https://rainorganica.com/products/craft-your-own-body-oil-for-menstrual-cycle-support-july-29th-affirmations-of-wellness-yoga-studio Watch the YouTube video here. Find the full shownotes (including transcript) at this link.

Are you wondering which essential oils best support PMS and menstrual cramps? If you answered “yes!”, you’re in the right place. In this episode, we explore the benefits of specific essential oils known for their soothing and therapeutic properties including: • Vitex berry essential oil • Clary sage • Vetiver • Frankincense • Rose And lavender (because how could any list of therapeutic essential oils be complete without lavender?) In the first half of this video, you’ll discover how your cycle works and what hormone imbalances may be contributing to mood swings, cramps, and nausea either during your premenstrual phase or during your period itself. Once we’ve set this foundation, then we’ll talk about how each of those essential oils listed above helps support hormone balance in your cycle or improves your body’s ability to handle the hormonal fluctuations that accompany your period. Join us as we delve into the science-backed benefits of these specific essential oils for supporting a healthy, pain-free period. Watch this video now for a natural approach to a healthy cycle. Download your essential oil blends for menstrual cycle support: PMS and painful periods edition here. Other episodes you may find interesting: Which cycle awareness method's right for you? Aromatherapy and Skincare: Inspiring Wellness Inside and Out with Osmia Skincare founder, Dr. Sarah Villafranco Exercising according to your menstrual cycle with Amy Oldfield