Healthcare Unfiltered

Neeta Somaiah, MD, of The University of Texas MD Anderson Cancer Center, provides a comprehensive overview of bone and soft tissue sarcomas, exploring how molecular classification and histology guide treatment decisions, the major therapeutic breakthroughs and drug approvals that have reshaped the field over the past decade, and current approaches to curative-intent therapy, including surgery, radiation, and adjuvant treatment strategies. The conversation also examines the management of advanced sarcoma, highlighting recent advances, ongoing challenges, and where the field is headed for patients with these complex malignancies. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi speaks with Michael Karlfeldt, ND, PhD, a board-certified naturopathic doctor, integrative medicine expert, and author of Breast Cancer Breakthrough: Integrating Conventional & Natural Medicine for True Healing, about evidence-informed complementary approaches to breast cancer care. They discuss how nutritional strategies, stress management, sleep optimization, toxin reduction, and other supportive interventions can be safely integrated alongside conventional breast cancer treatments, the inspiration behind his book, and why his protocols are designed to complement—not replace—standard oncology care. The conversation also explores the challenges of limited clinical evidence for integrative medicine, how Dr. Karlfeldt evaluates available research, and what patients, caregivers, and oncology professionals should know about incorporating supportive therapies into comprehensive breast cancer treatment. View more on the book. https://bookshop.org/p/books/breast-cancer-breakthrough-integrating-conventional-natural-medicine-for-true-healing-michael-karlfeldt/78fd09a593531461 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi Nabhan sits down with Saad Shahzad, co-founder of ZoomLogi, to explore how AI is revolutionizing healthcare logistics by improving the delivery of high-value, time-sensitive therapies, including cell and gene therapies, specialty pharmaceuticals, and biologics. They discuss the costly challenges of shipment delays, chain-of-custody issues, and fragmented supply chain systems, and how ZoomLogi's AI-powered platform provides real-time visibility across carriers, predicts disruptions before they occur, and delivers precise shipment ETAs to help ensure life-saving treatments reach patients safely and on time. Read more about ZoomLogi. https://www.zoomlogi.com/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

On this inagural and special episode of Healthcare Unfiltered -Arabic Edition, Nagla and I host the world-renowned actor and artist, Mr. Ahmed Shaker, who candidly shares his career journey and how he almost went into medicine. Mr. Shaker who speaks 3-4 languages has risen to fame through many series that were watched by millions. He discusses with us how art can help patients and how artists can use their fame, reach, and people's trust to disseminate health information and to help people combat fake data that may be all over social media. Mr. Shaker also shares his journey as a caregiver of his wonderful mom who was affected by cancer and how he navigated the healthcare system. Mr. Shaker wants and is making a difference, and we are very grateful that he joined us on our show. Please share this show with your friends and colleagues, and don't forget to subscribe, review, and join the conversation نستضيف أنا ونجلاء الفنان والممثل العالمي الأستاذ أحمد شاكر ، الذي يشاركنا بصراحة رحلته الفنية والمهنية، وكيف كاد أن يختار دراسة الطب بدلًا من الفن. يتحدث الأستاذ شاكر، الذي يجيد ثلاث إلى أربع لغات وحقق شهرة واسعة من خلال العديد من المسلسلات التي تابعها الملايين، عن الدور الذي يمكن أن يلعبه الفن في مساعدة المرضى، وكيف يستطيع الفنانون توظيف شهرتهم وتأثيرهم وثقة الجمهور بهم لنشر المعلومات الصحية الموثوقة والمساهمة في مواجهة المعلومات المضللة المنتشرة عبر وسائل التواصل الاجتماعي. كما يشاركنا تجربته الشخصية كمرافق ومساند لوالدته الرائعة خلال إصابتها بالسرطان، وما تعلمه من رحلته معها في التعامل مع منظومة الرعاية الصحية. الأستاذ أحمد شاكر حريص على إحداث فرق حقيقي، وهو بالفعل يفعل ذلك، ونحن ممتنون جدًا لانضمامه إلينا في هذه الحلقة المميزة.

World-renowned MPN expert Dr. Prithviraj Bose of MD Anderson Cancer Center joins Chadi to explore the latest advances in myeloproliferative neoplasms (MPNs), including the molecular drivers of polycythemia vera, essential thrombocythemia, and myelofibrosis, and how these discoveries are reshaping patient care. The conversation then turns to the landmark phase 3 SENTRY trial, which evaluated frontline selinexor plus ruxolitinib versus ruxolitinib alone for patients with JAK inhibitor–naïve myelofibrosis—a rare blood cancer characterized by bone marrow scarring, splenomegaly, and debilitating symptoms. Dr. Bose discusses the trial's potentially practice-changing results, the benefits and limitations of the combination regimen, and what the data mean for the future standard of care in myelofibrosis. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by two of the world's leading multiple myeloma experts, Dr. Sagar Lonial of Emory University and Dr. Vincent Rajkumar of Mayo Clinic, for an in-depth discussion of the latest advances in multiple myeloma presented at the European Hematology Association (EHA) Congress in Stockholm. They explore the emerging class of cereblon E3 ligase modulators (CELMoDs), explaining how these next-generation therapies differ from existing immunomodulatory drugs, the science behind their mechanism of action, and why they are generating so much excitement in the field. The conversation also reviews the key clinical trial data unveiled at EHA, discusses where CELMoDs may fit into the evolving treatment landscape, and looks ahead to the breakthroughs that could shape multiple myeloma care in the years to come. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

How is decision-making shaped in hematology? In a setting where evidence from randomized clinical trials, real-world data, and the uncertainties inherent in everyday clinical practice coexist, how do we analyze the available information to make the best treatment decisions for our patients? Cómo se construye la toma de decisiones en hematología? En un escenario donde conviven la evidencia de los estudios clínicos aleatorizados, los datos del mundo real y las incertidumbres inherentes a la práctica diaria, cómo analizamos la información disponible para tomar las mejores decisiones terapéuticas para nuestros pacientes?

Advanced Practice Providers (APPs)—including physician assistants (PAs) and nurse practitioners (NPs)—are playing an increasingly vital role in meeting the growing demand for high-quality cancer care. Corinne Shamehdi, PA-C, a hematology/oncology physician assistant and educator with NCODA, sits down with Chadi and discusses why the APP workforce is expanding, how PAs and NPs are trained, the evolving relationship between APPs and physicians, and addresses common misconceptions surrounding their role in oncology practice. The conversation also explores licensure across state lines, career advancement opportunities, and how oncology APPs stay current with the rapid pace of new cancer therapies and clinical evidence, offering an inside look at one of the fastest-growing segments of the oncology workforce. NCODA is a non-profit organization that supports the full oncology care team through education, quality standards, and best practices. If you're an Oncology APP or a member of the oncology care team, you can learn more and join NCODA. Membership is complimentary. Join here: https://bit.ly/NCODAHealthcareUnfiltered Find out more about NCODA. https://ncoda.org/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Cardiologist and “The Doctor's Lounge” host Anish Koka, MD, joins the show to examine the extraordinary ChemoCentryx and Tavneos (avacopan) controversy, including the retraction of a New England Journal of Medicine clinical trial that played a key role in the drug's FDA approval for ANCA-associated vasculitis. Based on his Substack investigation, Dr. Koka breaks down the timeline of events, the concerns surrounding post hoc changes to trial endpoints, the FDA's response, and the far-reaching implications for clinical trial integrity, drug development, pharmaceutical regulation, and evidence-based medicine. Tune in for a thought-provoking discussion on scientific transparency, regulatory oversight, and what this high-profile case means for physicians, researchers, the pharmaceutical industry, and patients alike. Read the substack article. https://anishkokamd.substack.com/p/we-cannot-afford-to-miss-a-superiority Subscribe to The Doctor's Lounge. https://podcasts.apple.com/us/podcast/the-doctors-lounge/id1832097658 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this special episode, Chadi sits down with one of the most influential figures in modern leukemia research and care: Hagop M. Kantarjian, MD, Professor and Samsung Distinguished Leukemia Chair in Cancer Medicine at The University of Texas MD Anderson Cancer Center. Dr. Kantarjian reflects on four decades of progress in leukemia treatment, discussing how the field has evolved from an era of limited therapeutic options to one transformed by groundbreaking scientific advances, while offering his perspective on risk stratification across favorable, less favorable, and high-risk leukemias. The conversation spans chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML), including the promise of triplet and quadruplet regimens and the urgent need for better therapies in secondary leukemias. Combining historical perspective, clinical insight, and a vision for the future, this episode is a rare opportunity to hear from a physician-scientist whose work has helped shape the modern treatment landscape for patients with leukemia worldwide. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Andy Moye—author of From Bunker Hill to the Boardroom—to explore the battle-tested leadership principles that shaped his journey from military service to executive leadership in biotechnology, life sciences, molecular diagnostics, and artificial intelligence. Moye shares why empathy is the cornerstone of effective leadership, how leaders must develop “adaptive intelligence” by letting go of preconceived solutions and responding to evolving challenges, and the critical mistakes executives continue to make in healthcare today. The conversation also examines the future of AI in pathology and healthcare innovation, offering practical insights for current and aspiring leaders on navigating uncertainty, driving meaningful change, and building organizations that are prepared for the rapidly evolving healthcare landscape. Read more about the book. https://us.amazon.com/Bunker-Hill-Boardroom-Battle-Tested-Leadership-ebook/dp/B0H2BTXFL8 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by renowned gastrointestinal oncologists, Tanios S. Bekaii-Saab, MD, of Mayo Clinic, and Shubham Pant, MD, MBBS, of MD Anderson Cancer Center, to discuss the groundbreaking findings from the RASolute 302 trial, recently published in The New England Journal of Medicine and presented to a standing ovation during the plenary session at the 2026 ASCO Annual Meeting. Dr. Pant, a study author, provides an insider's perspective on how RAS inhibition is reshaping the treatment landscape for pancreatic cancer, including where these therapies may fit in the current treatment paradigm and how clinicians should manage their unique toxicity profiles. The conversation also looks ahead to the next generation of studies, including RASolute 303 and RASolute 304, and what these trials could mean for the future of precision medicine in pancreatic cancer. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Ezra Cohen, MD, Chief Medical Officer of Oncology at Tempus AI, for an in-depth discussion on the evolving role of next-generation sequencing (NGS) across the cancer continuum. Together, they explore how tissue-based testing, liquid biopsy, and measurable residual disease (MRD) assessments are reshaping precision oncology, why NGS remains underutilized in many patients, and the educational efforts needed to ensure genomic testing is ordered and applied appropriately to improve outcomes. Dr. Cohen also examines the growing role of artificial intelligence in interpreting and integrating genomic data, including Tempus' embedded AI tools designed to support both clinicians and patients. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Healthcare Unfiltered Podcast and FASE 3 Podcast are collaborating on a new venture called "Hematology Sin Filtros" - a new podcast in Spanish that will be broadcasted once a month discussing various topics in hematology and cancer. Please share with your friends, colleagues and subscribe and join the conversation. Los podcasts *Healthcare Unfiltered* y *FASE 3* colaboran en una nueva iniciativa llamada "Hematology Sin Filtros": un nuevo podcast en español que se emitirá una vez al mes para abordar diversos temas de hematología y oncología. Por favor, compártelo con tus amigos y colegas, suscríbete y únete a la conversación.

In this deeply personal episode, Gabby shares her extraordinary journey of being diagnosed with stage IV metastatic colorectal cancer with liver involvement during the final stages of her pregnancy. She discusses the emotions and decisions surrounding her diagnosis, what she looked for when choosing her oncology team, how openly she communicated with her husband and young children, and the realities of navigating cancer treatment while welcoming a new baby. Gabby also reflects on documenting her experience in real time on social media, exploring both the support and challenges that come with sharing such an intimate journey publicly, while offering insight into the many clinical and personal decisions she has faced along the way. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Maen Abdelrahim, MD, PhD, Section Chief of Gastrointestinal Medical Oncology at Houston Methodist Neal Cancer Center—home to the nation’s highest-volume liver transplant program—joins the show to discuss the expanding field of transplant oncology, including which patients with hepatocellular carcinoma, colorectal cancer metastatic to the liver, biliary cancers, and intrahepatic cholangiocarcinoma may benefit from liver transplantation. He explores the history of liver transplantation and the development of the Milan criteria, how those advances paved the way for transplant oncology as a multidisciplinary specialty, and the ongoing educational gaps surrounding transplant eligibility and referral. Dr. Abdelrahim also shares insights from his book, “Transplant Oncology: A Frontier in Multidisciplinary Cancer Care,” while discussing the evolving role and safety of immunotherapy and ctDNA in the peri-transplant setting and the future of cancer care for patients once considered untreatable. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts Dr. Chandana Banerjee of City of Hope and Kevin Diaz, CEO and President of Compassion & Choices, for a thoughtful conversation about Medical Aid in Dying (MAID) – what it is, who qualifies, how the process works, and why it remains one of the most debated issues in modern healthcare. Together, they explore the legal, ethical, and cultural complexities surrounding MAID, including the differences between MAID, assisted suicide, and euthanasia, the role of physicians and hospice care, the history and legal challenges of MAID legislation in the US, and the deeply personal realities patients and families face when navigating terminal illness, especially when loved ones disagree about care goals or when palliative and hospice care are no longer enough. Read more about Compassion and Choices. https://compassionandchoices.org/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Dr. Daniel Olson to discuss the growing excitement surrounding tumor-infiltrating lymphocyte (TIL) therapy in melanoma, including how these personalized cellular therapies are created (and sometimes engineered in the lab), the logistical challenges of collection and reinfusion, and the clinical data that led to FDA approval based on a single-arm study. Dr. Olson also explores treatment sequencing with immunotherapy and targeted therapy, the severity and duration of associated toxicities, response rates seen in practice, and the expanding potential for TIL therapy in other malignancies such as lung and cervical cancers, offering a practical and forward-looking look at one of the most promising advances in solid tumor oncology. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by Dr. Sewanti Limaye to discuss what precision oncology looks like in India, exploring the realities of access, affordability, infrastructure, and innovation in cancer care. Drawing on her experience training and practicing in the United States before returning to Mumbai to lead oncology and translational research programs, Dr. Limaye explains which genomic tests, liquid biopsies, and targeted therapies are currently available in India, the challenges surrounding out-of-pocket costs and insurance coverage, and why helping even a small percentage of patients access precision medicine can have a major impact. The conversation also covers clinical trial capabilities, lab turnaround times, international players in the liquid biopsy space, and the complexities of FDA-approved drugs that remain unavailable for prescription in India. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with sit down with Sue S. Yom, MD, PhD, FASTRO—radiation oncologist at UCSF, Editor-in-Chief of the International Journal of Radiation Oncology Biology Physics, and leader within NRG Oncology—to explore the critical role of cooperative groups in advancing cancer research. She unpacks their history, the benefits and challenges of large-scale collaboration, and how federal funding and partnerships with industry shape the design and execution of clinical trials. Dr. Yom also shares insights from her editorial perspective and highlights what’s ahead in radiation oncology, including the growing role of biomarkers, personalized treatment strategies, and smarter sequencing of therapies. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA