AAAAI Podcast: Conversations from the World of Allergy

Innate lymphoid cells or ILCs respond rapidly to help defend mucosal barriers, maintain tissue homeostasis and shape the adaptive immune response that follows. In this episode, Taylor A. Doherty, MD, FAAAAI, will discuss the importance of ILCs and what we know about these uniquely positioned cells in allergic disease.

Eosinophilia has a broad differential and determining how to most effectively evaluate it can be challenging. In this episode, we’ll work through a clinical case with Paneez Khoury, MD, MHSc, FAAAAI, and discuss how understanding eosinophil biology can guide our evaluation and management.

Gene editing has moved from the laboratory to the clinic and is likely to transform treatment for our patients with inborn errors of immunity. In this episode, Caroline Kuo, MD, explains genome editing technologies and how these tools may enable precise, potentially curative therapies.

The LEAP trial fundamentally changed our understanding of immune tolerance, demonstrating that early oral exposure can dramatically reduce the risk of developing peanut allergy. In this episode, Edwin Kim, MD, FAAAAI, will help us explore the immunologic mechanisms of early food introduction and tolerance development and what the evidence tells us about other food allergies.

Join us as Kelly Stone, MD, PhD, FAAAAI, explains the evolution of the U.S. Food and Drug Administration and its central role in ensuring the safety and efficacy of therapeutics in the United States. We discuss the modern drug approval process from preclinical development through clinical trials and post-marketing surveillance and explore what makes this pathway different for biologics and biosimilars so you have a better understanding of the therapeutics that we prescribe every day in the clinic. Biosimilars MedWatch: The FDA Safety Information and Adverse Event Reporting Program FDA History Drug Development Process

Join us as Derek Chu, MD, PhD, explores the paradigm shift in treating atopic dermatitis as a systemic, immune-driven disease rather than a localized skin condition. We discuss the updates to the practice parameters including practical guidance on integrating of novel topicals, biologics, and JAK inhibitors into our treatment as well as the upcoming practice parameters on chronic spontaneous urticaria. Continuing Medical Education credit is available with this episode. Complete the assessment and claim credit. .75 AMA PRA Category 1 Credit(s)™

Join us as Monica Kraft, MD, FAAAAI, provides an evidence-based framework for managing allergic conditions during pregnancy, focusing on the safety of commonly used medications, from inhaled corticosteroids and antihistamines to biologics. We address the risks of undertreated asthma and explore the latest recommendations for penicillin allergy delabeling to optimize maternal-fetal outcomes. The discussion offers practical strategies for collaborating with OB-GYN colleagues to ensure safe, effective treatment throughout every trimester. View the Work Group Report: Penicillin Allergy Delabeling Can and Should Be Performed in Pregnant Patients: A Work Group Report of the AAAAI Women’s Health in Allergy and Immunology and Adverse Reaction to Drugs, Biologics and Vaccines Committees

In this episode, Christine Cho, MD, FAAAAI, discusses analyzing medical errors within the allergy clinic, from incorrect immunotherapy dosing to the systemic risks of penicillin mislabeling. Dr. Cho explains how shifting from a culture of blame to a "just culture" allows practices to transform "near misses" into learning opportunities that create more robust, reliable systems.

In honor of Food Allergy Awareness Week, we’re stepping out of the clinic and into the heat of the kitchen. Chef Ming Tsai shares an insider’s look at restaurant safety protocols, food allergy legislation and practical strategies physicians need to help patients with food allergies navigate the world with confidence. Find out more about food allergies.

In this episode, we discuss the remarkable evolution of allergy and immunology through the lens of a career spanning six decades. Past AAAAI President Phil Lieberman, MD, FAAAAI, explores the pivotal scientific breakthroughs in the field starting with the discovery of IgE as he started in practice and taking us through target therapy has changed the lives of his patients. Dr. Lieberman offers us both historical perspective and guidance for physicians just starting in the field. Find out more about Dr. Lieberman.

Climate change is reshaping the landscape of allergy and immunology in ways that directly affect human health. In this episode, Jeffrey G. Demain, MD, FAAAAI, discusses how rising temperatures, shifting weather patterns and increased carbon dioxide levels are intensifying allergic diseases and altering immune responses worldwide.

AAAAI President Carla Davis, MD, FAAAAI, discusses her journey in allergy / immunology including key mentors and the initiatives in education, research and advocacy that she will be advancing over the next year. Learn how you can access education tailored to your interests through AAAAI Ignite and advocate for your patients through AAAAI Advocate. AAAAI Advocate

Alpha-gal syndrome has transformed our understanding of food allergy, linking tick bites to delayed anaphylaxis to mammalian meats. In this episode, we explore the epidemiology, immunologic mechanisms, diagnosis and management of alpha-gal syndrome with expert Scott Commins, MD, FAAAAI. Join us for practical clinical pearls and emerging insights into this unique disease. Continuing Medical Education credit is available with this episode. Visit here to complete the assessment and claim credit. .75 AMA PRA Category 1 Credit(s)™ . Find out more about alpha-gal.

GLP-1 agonists have been blockbuster medications in diabetes and obesity but they may also have a surprising role in the treatment of asthma. Join the conversation as Katherine Cahill, MD, FAAAAI, discusses how GLP-1 agonists may improve asthma control and reduce airway inflammation. Find out more about asthma.

Vaccines are a cornerstone of public health, training the immune system to prevent infectious diseases, especially in our most vulnerable patients. In this episode, John Kelso, MD, FAAAAI, reviews recent vaccine developments, including the importance of measles vaccination amid ongoing outbreaks, updates to vaccination schedules, considerations when using vaccines with biologics and evaluation of vaccine allergy. Join us for a practical review of key vaccine updates to help you protect your patients. Find out more about the importance of vaccinations across age groups.

Improving access to penicillin allergy evaluation for millions of older patients would lead to better antibiotic treatment, decreased surgical site infections and fewer cases of C. diff. The Penicillin Allergy Verification and Evaluation Act has the potential to do just this. Priya Bansal, MD, FAAAAI, and Allison Ramsey, MD, FAAAAI, share their valuable insight into the Act and how we can make advocacy a part of our practice. Find out more about the Penicillin Allergy Verification and Evaluation Act

Julie Wang, MD, FAAAAI, shares highlights of the upcoming AAAAI Annual Meeting taking place in Philadelphia, Pennsylvania from February 27 to March 2. Listen in to hear what is in store this year as well as highlights such as the symposium on Philadelphia’s vaccine legacy as well as use of Artificial Intelligence and the new Practice Management Course. Visit the AAAAI Annual Meeting website.

As immunosuppressive therapies for cancer and autoimmune disease become more common, secondary immune deficiency is increasingly encountered in clinical practice. In this episode, Sara Barmettler, MD, FAAAAI, discusses the causes, diagnosis and management of secondary immune deficiency to help allergy and immunology physicians care for these patients effectively.

Join hereditary angioedema expert Aleena Banerji, MD, FAAAAI, for a discussion about the diagnosis and management of hereditary angioedema, focusing on treatment developments that have dramatically improved the care of patients with HAE. Continuing Medical Education credit is available with this episode. Visit here to complete the assessment and claim credit. .75 AMA PRA Category 1 Credit(s )™ Find out more about hereditary angioedema. US Hereditary Angioedema Association

Diagnosing Food Protein Induced Enterocolitis Syndrome (FPIES) can be challenging and once diagnosed, there are few options for treatment other than strict avoidance and waiting for resolution. Sara Anvari, MD, MSc, FAAAAI, discusses the presentation and pathophysiology of FPIES and how treatment options beyond avoidance are evolving. Continuing Medical Education credit is available with this episode. Visit here to complete the assessment and claim credit. .75 AMA PRA Category 1 Credit(s) ™ FPIES (Food Protein-Induced Enterocolitis Syndrome) Action Plan